Single point insulin sensitivity estimator index and incident impaired fasting glucose in Chinese adults: a retrospective cohort study - Scorecard - MDSpire
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Single point insulin sensitivity estimator index and incident impaired fasting glucose in Chinese adults: a retrospective cohort study
Clinical Scorecard: Association of the Single Point Insulin Sensitivity Estimator Index with the Risk of Developing Impaired Fasting Glucose in Chinese Adults: A Retrospective Cohort Analysis
At a Glance
Category
Detail
Condition
Impaired Fasting Glucose (IFG)
Key Mechanisms
Insulin resistance as the core pathophysiological mechanism
Target Population
Chinese adults with normal fasting plasma glucose
Care Setting
Community-based
Key Highlights
Higher SPISE index associated with lower risk of IFG
12.33% incidence of IFG during a median follow-up of 2.99 years
Each one-unit increase in SPISE index linked to a hazard ratio of 0.91 for incident IFG
Participants in Q4 had approximately 40% lower risk of developing IFG compared to Q1
Linear inverse association between SPISE index and IFG risk
Guideline-Based Recommendations
Diagnosis
Utilize SPISE index for identifying individuals at high risk for IFG
Management
Implement targeted primary prevention strategies for diabetes based on SPISE index
Monitoring & Follow-up
Regular assessment of SPISE index in at-risk populations
Risks
Individuals with IFG face increased risk of progressing to diabetes and cardiovascular disease
Patient & Prescribing Data
Chinese adults with normal fasting plasma glucose
SPISE index could serve as a simple and cost-effective tool for risk identification
Clinical Best Practices
Incorporate SPISE index in routine clinical practice for early identification of IFG risk
Conduct subgroup and sensitivity analyses to verify robustness of results
