Analysis of Treatment Approaches and Survival Rates in Older Adults with Intrahepatic Cholangiocarcinoma: Insights from the NCDB
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By
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Haytham Effarah
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Jino Park
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Garrett Harada
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David Hong
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Caressa Hui
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July 20, 2026
Clinical Scorecard: Analysis of Treatment Approaches and Survival Rates in Older Adults with Intrahepatic Cholangiocarcinoma: Insights from the NCDB
At a Glance
| Category | Detail |
|---|
| Condition | Intrahepatic Cholangiocarcinoma (ICC) |
| Key Mechanisms | Surgical resection, chemotherapy, radiotherapy |
| Target Population | Older adults (>65 years) |
| Care Setting | Oncology treatment settings |
Key Highlights
- Elderly patients with ICC are less likely to receive aggressive treatment options.
- Surgery is associated with improved survival compared to nonsurgical approaches.
- Chemotherapy plus radiotherapy improves survival in nonsurgical elderly patients.
- Elderly patients are underrepresented in clinical trials for ICC.
- Treatment de-intensification is common in elderly patients with ICC.
Guideline-Based Recommendations
Diagnosis
- Diagnosis of ICC should be confirmed using ICD-O-3 coding.
Management
- Consider surgical resection for operable ICC.
- Utilize systemic therapy for inoperable ICC cases.
Monitoring & Follow-up
- Monitor overall survival rates based on treatment modalities.
Risks
- Elderly patients may face increased risks due to comorbidities and treatment de-intensification.
Patient & Prescribing Data
Patients diagnosed with nonmetastatic ICC from 2004 to 2020.
Elderly patients are more likely to receive surgery alone and less likely to receive trimodality therapy.
Clinical Best Practices
- Incorporate surgical options for eligible elderly patients.
- Evaluate the use of chemotherapy and radiotherapy in combination for improved outcomes.
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