Anti-CD146 Linked to Silica in Systemic Sclerosis

Comparative analysis across exposed workers, cancer controls, and healthy donors supports specificity.

Category	Detail
Condition	Systemic Sclerosis
Key Mechanisms	Association of anti-CD146 autoantibodies with occupational exposure, particularly to crystalline silica.
Target Population	Patients with systemic sclerosis, particularly those with occupational exposure.
Care Setting	Retrospective monocentric cohort study.

15% of systemic sclerosis patients tested positive for anti-CD146 autoantibodies.
Anti-CD146 positivity associated with male sex and silica exposure.
57% sensitivity and 88% specificity for occupational exposure.
29% of antibody-positive patients had silica exposure.
No association found between anti-CD146 and disease severity.

Use anti-CD146 autoantibody testing as a potential biomarker for systemic sclerosis related to occupational exposure.

Monitor for interstitial lung disease in patients with positive anti-CD146 status.

Patients diagnosed with systemic sclerosis according to 2013 classification criteria.

No specific treatment insights provided; focus on diagnosis and occupational exposure.

Incorporate occupational exposure assessment in systemic sclerosis evaluations.
Utilize anti-CD146 testing in patients with suspected occupational systemic sclerosis.