Harmonization of social and physical health measures across prospective clinical studies of combat exposed service members and veterans: the total brain diagnostics program - Scorecard - MDSpire
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Harmonization of social and physical health measures across prospective clinical studies of combat exposed service members and veterans: the total brain diagnostics program
Clinical Scorecard: Standardization of Social and Physical Health Metrics in Clinical Research Involving Combat-Exposed Veterans and Service Members: Insights from the Total Brain Diagnostics Initiative
At a Glance
Category
Detail
Condition
Traumatic Brain Injury (TBI)
Key Mechanisms
Harmonization of psychosocial and physical health metrics
Target Population
Veterans and active-duty service members
Care Setting
Clinical research involving longitudinal cohort studies
Key Highlights
Utilized data from LIMBIC and TRACTS studies to address research gaps in TBI outcomes.
Harmonized 73 variables related to psychosocial function and clinical health factors.
Conducted Principal Component Analysis to assess data suitability for pooled analysis.
Focused on baseline data harmonization to enhance future longitudinal studies.
Identified the need for comprehensive data to inform targeted treatments for TBI.
Guideline-Based Recommendations
Diagnosis
Utilize comprehensive symptom scales and objective assessments for TBI.
Management
Implement precision medicine approaches based on harmonized data.
Monitoring & Follow-up
Regularly assess psychosocial and physical health outcomes in veterans and service members.
Risks
Consider the impact of TBI on long-term psychosocial and functional changes.
Patient & Prescribing Data
Combat-exposed veterans and service members with a history of TBI.
Harmonized data can lead to more personalized treatment strategies.
Clinical Best Practices
Employ multidisciplinary teams for data harmonization.
Utilize both direct and indirect harmonization methods for clinical measures.
Focus on longitudinal data collection to enhance understanding of TBI outcomes.
by Shannon M. Nugent, Kate Clauss, Sara Vlajic, Maya E. O’Neil, Samuel R. Walton, Kelly M. Reavis, Christine Clermont, Alyssa Currao, Cree Foeller, Catherine B. Fortier, Sreekanth Kamineni, Arielle R. Knight, Aubrey A. Knoff, Landon B. Lempke, Helal Mobasher, William C. Walker, William P. Milberg, David X. Cifu
