Molecular Analysis of Influenza A (A/H3N2) Viruses Indicates Antigenic Drift in the Receptor Binding Domain and Potential Vaccine Mismatch Among Strains in Riyadh, Saudi Arabia, 2024–2025 - Scorecard - MDSpire
Advertisement
Molecular Analysis of Influenza A (A/H3N2) Viruses Indicates Antigenic Drift in the Receptor Binding Domain and Potential Vaccine Mismatch Among Strains in Riyadh, Saudi Arabia, 2024–2025
Clinical Scorecard: Molecular Analysis of Influenza A (A/H3N2) Viruses Indicates Antigenic Drift in the Receptor Binding Domain and Potential Vaccine Mismatch Among Strains in Riyadh, Saudi Arabia, 2024–2025
At a Glance
Category
Detail
Condition
Key Mechanisms
Target Population
Individuals presenting with influenza-like illness (ILI) in Riyadh, Saudi Arabia, including specific age groups and risk factors.
Care Setting
Key Highlights
A/H3N2 viruses show significant antigenic drift since 1968, impacting vaccine effectiveness and public health.
Guideline-Based Recommendations
Diagnosis
Management
Continuous genetic and antigenic monitoring to guide vaccine reformulation.
Consider antiviral treatments based on current guidelines.
Monitoring & Follow-up
Risks
Patient & Prescribing Data
Monitoring of circulating strains is essential for effective vaccine policy; specify exclusion criteria for vaccinated individuals.
Clinical Best Practices
Conduct comprehensive molecular characterization of circulating strains.
Ensure ethical standards and patient confidentiality in sample handling.
Educate patients on influenza prevention strategies.
by Shatha Ata Abdulgader, Ibrahim M. Aziz, Abdulhadi M. Abdulwahed, Mohamed A. Farrag, Reem M. Aljowaie, Abdulaziz M. Almuqrin, Noorah A. Alkubaisi, Fahad N. Almajhdi
