Emergence of Linezolid Resistance in Drug-Resistant Tuberculosis: Analyzing Genotype-Phenotype Discrepancies and Molecular Diversity in a Retrospective Study - Scorecard - MDSpire

Emergence of Linezolid Resistance in Drug-Resistant Tuberculosis: Analyzing Genotype-Phenotype Discrepancies and Molecular Diversity in a Retrospective Study

  • By

  • Wenqiang Zhou

  • Qingfeng Wang

  • Wenjuan Nie

  • Wenhui Shi

  • Yang Yang

  • Wenjie Qi

  • Yu Lu

  • Naihui Chu

  • February 14, 2026

  • 0 min

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Clinical Scorecard: Emergence of Linezolid Resistance in Drug-Resistant Tuberculosis: Analyzing Genotype-Phenotype Discrepancies and Molecular Diversity in a Retrospective Study

At a Glance

CategoryDetail
Condition
Key MechanismsLinezolid inhibits bacterial protein synthesis; resistance arises from ribosomal mutations (e.g., rplC, rrl) and non-ribosomal mechanisms.
Target Population
Care Setting

Key Highlights

  • success_rates

Guideline-Based Recommendations

Diagnosis

    Management

    • C
    • o
    • n
    • s
    • i
    • d
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    Monitoring & Follow-up

      Risks

        Patient & Prescribing Data

        Empirical prescribing is common due to lack of standardized susceptibility testing, which can lead to treatment failures.

        Clinical Best Practices

        • diagnostics

        References

        Original Source(s)

        Emergence of Linezolid Resistance in Drug-Resistant Tuberculosis: Analyzing Genotype-Phenotype Discrepancies and Molecular Diversity in a Retrospective Study

        • by Wenqiang Zhou, Qingfeng Wang, Wenjuan Nie, Wenhui Shi, Yang Yang, Wenjie Qi, Yu Lu, Naihui Chu

        • February 14, 2026

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