Comparative effectiveness of statins, metformin, and vitamin D, for prevention of preeclampsia: a systematic review and network meta-analysis of randomized trials - Scorecard - MDSpire
Coming Soon: Introducing MDSpire News. Learn more
Conexiant’s news site is now MDSpire News. Learn more

Efficacy Comparison of Statins, Metformin, and Vitamin D in Preeclampsia Prevention: A Systematic Review and Network Meta-Analysis of Randomized Trials

  • By

  • Menna Alaa El-Khouly

  • Mazen Mohammed Mahgoub

  • Mahmoud E. Abd-Elkareem

  • Noreen M. El-Bayaa

  • Jana M. Farouk

  • Mariam M. Fouad

  • Habiba Mohammed Salah

  • Ahmed Khaled Saad

  • Mohammed Al-azab

  • Rofida Ayman Mohamed

  • Kholoud Dahshan

  • Dalia Atef Abouda

  • October 2, 2026

Share

Clinical Scorecard: Efficacy Comparison of Statins, Metformin, and Vitamin D in Preeclampsia Prevention: A Systematic Review and Network Meta-Analysis of Randomized Trials

At a Glance

CategoryDetail
ConditionPreeclampsia
Key MechanismsImpaired spiral artery remodeling, systemic inflammatory response, endothelial dysfunction, anti-angiogenic state.
Target PopulationHigh-risk pregnant women
Care SettingObstetric care

Key Highlights

  • Preeclampsia affects 2%-8% of pregnancies globally.
  • Low-dose aspirin is the only recommended preventive intervention for high-risk women.
  • Statins, metformin, and vitamin D are investigated for their potential in preventing preeclampsia.
  • Metformin may decrease the incidence of superimposed pre-eclampsia.
  • Vitamin D supplementation may reduce pre-eclampsia risk, but effects on neonatal outcomes are unclear.

Guideline-Based Recommendations

Diagnosis

  • Preeclampsia is diagnosed by hypertension and proteinuria after 20 weeks of gestation.

Management

  • Low-dose aspirin is recommended for high-risk women.

Monitoring & Follow-up

  • Monitor for gestational hypertension, premature delivery, and related adverse outcomes.

Risks

  • Preeclampsia confers lifelong cardiovascular disease risks on mothers and adverse outcomes for offspring.

Patient & Prescribing Data

Pregnant individuals designated as having high-risk pregnancies.

Investigated agents include pravastatin, metformin, and vitamin D, with varying evidence of efficacy.

Clinical Best Practices

  • Utilize low-dose aspirin for high-risk pregnant women.
  • Consider alternative agents like metformin and vitamin D in clinical discussions.

Related Resources & Content

Original Source(s)

Comparative effectiveness of statins, metformin, and vitamin D, for prevention of preeclampsia: a systematic review and network meta-analysis of randomized trials

  • by Menna Alaa El-Khouly, Mazen Mohammed Mahgoub, Mahmoud E. Abd-Elkareem, Noreen M. El-Bayaa, Jana M. Farouk, Mariam M. Fouad, Habiba Mohammed Salah, Ahmed Khaled Saad, Mohammed Al-azab, Rofida Ayman Mohamed, Kholoud Dahshan, Dalia Atef Abouda

  • October 2, 2026

Related Content

Hinoki root oil may reduce nighttime wakefulness

Women exposed to Japanese cypress root volatiles for 13 days reported less morning sleepiness and better fatigue recovery in a small crossover study.

Where Women Veterans Seek Emergency Care: Patterns and Predictors of VA and Community Emergency Department Use

Early indicators of NICU admission for ongoing respiratory support in caesarean-delivered late preterm and term neonates requiring non-invasive respiratory support within the first 15 min after birth: a post hoc analysis