Deciphering host–virus interaction networks in ALV infection: an integrative multi-omics perspective
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By
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Junliang Xia
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Weiding Chen
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Xiaoli Zhou
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Tao Xu
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Guodong Mo
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Xiquan Zhang
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June 30, 2026
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Clinical Scorecard: Analyzing Host-Virus Interaction Dynamics in Avian Leukosis Virus Infection: A Comprehensive Multi-Omics Approach
At a Glance
| Category | Detail |
|---|
| Condition | Avian Leukosis Virus Infection |
| Key Mechanisms | Persistent infection, immunosuppression, tumorigenesis, host-virus interactions. |
| Target Population | Poultry industry, particularly chickens. |
| Care Setting | Veterinary and poultry health management. |
Key Highlights
- ALV can establish lifelong infections and induce immunosuppression.
- Multi-omics technologies enhance understanding of host-virus interactions.
- CRISPR-based functional screening aids in identifying host factors.
- Subclinical infections complicate the evaluation of immune responses.
- ALV-J is the most pathogenic and economically significant subgroup.
Guideline-Based Recommendations
Diagnosis
- Utilize multi-omics approaches to assess host responses.
Management
- Implement rigorous eradication programs including testing and culling.
Monitoring & Follow-up
- Monitor for subclinical infections and viral evolution.
Risks
- Vertical transmission and contamination of vaccines pose significant risks.
Patient & Prescribing Data
Chickens in poultry farms.
Focus on integrating genomic and phenotypic data for effective management.
Clinical Best Practices
- Adopt multi-omics strategies for comprehensive analysis.
- Enhance biosecurity measures in poultry management.
- Regularly update eradication protocols based on emerging data.
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