Spinal cord stimulation for upper limb motor function in people with chronic post-stroke hemiparesis: a feasibility trial - Scorecard - MDSpire
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Evaluation of Spinal Cord Stimulation for Enhancing Upper Limb Motor Abilities in Individuals with Chronic Hemiparesis Following Stroke: A Feasibility Study

  • By

  • Roberto M. de Freitas

  • Shovan Bhatia

  • Erynn Sorensen

  • Nikhil Verma

  • Erick Carranza

  • Scott Ensel

  • Luigi Borda

  • Amy Boos

  • Jeff Goldsmith

  • Lee E. Fisher

  • Daryl P. Fields

  • Marc P. Powell

  • Shane Gordon

  • Jeffrey Balzer

  • Robert M. Friedlander

  • George F. Wittenberg

  • Peter C. Gerszten

  • John W. Krakauer

  • Elvira Pirondini

  • Douglas J. Weber

  • Marco Capogrosso

  • June 4, 2026

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Clinical Scorecard: Evaluation of Spinal Cord Stimulation for Enhancing Upper Limb Motor Abilities in Individuals with Chronic Hemiparesis Following Stroke: A Feasibility Study

At a Glance

Category

Detail

Condition

Chronic hemiparesis following stroke

Key Mechanisms

Epidural spinal cord stimulation (SCS) activates dorsal root afferents to improve motor function, providing both immediate assistive effects and long-term therapeutic benefits.

Target Population

Individuals with chronic hemiparesis post-stroke

Care Setting

Rehabilitation centers

Key Highlights

  • SCS improved strength, dexterity, spasticity, and movement synergies, with maximal efficacy observed when stimulation was ON.

  • Retention of motor improvements depends on continued use of SCS, with milder sensory impairments correlating with greater motor function improvements.

Guideline-Based Recommendations

Diagnosis

  • Comprehensive neurological assessment to confirm chronic hemiparesis and evaluate the extent of motor deficits.

  • Utilization of imaging studies (e.g., MRI, CT) to assess brain injury and rule out other causes of motor impairment.

Management

  • Implementation of a multidisciplinary rehabilitation program including physical therapy, occupational therapy, and SCS.

  • Regular adjustments to SCS parameters based on patient response and tolerance.

Monitoring & Follow-up

  • Daily motor assessments using standardized tools during SCS implant period.

Risks

  • Potential for infection at the implantation site.

  • Risk of lead migration or malfunction of the SCS device.

  • Possible adverse effects such as pain, discomfort, or changes in sensory perception.

Patient & Prescribing Data

SCS provides immediate assistive effects and potential long-term therapeutic benefits across diverse stroke etiologies.

Clinical Best Practices

  • Follow FDA regulations for non-significant risk studies and evaluate long-term outcomes post-implantation.

Related Resources & Content

  • Clinical Trial NCT04512690

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Original Source(s)

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