Potential role of maintaining physiological testosterone levels in improving glucose metabolism among normal-weight Japanese women: a pilot exploratory study

Category	Detail
Condition	Glucose Metabolism Impairment
Key Mechanisms	Inverse correlation between total testosterone levels and glucose metabolism indices (HbA1c, fasting plasma glucose, HOMA-IR).
Target Population	Normal-weight Japanese women (BMI 18.5–25 kg/m²).
Care Setting	Health screening facility.

Total testosterone levels inversely correlated with HbA1c, fasting glucose, and HOMA-IR.
Significant associations remained after adjusting for BMI and lifestyle factors.
Inverse association between testosterone and HOMA-IR remained significant after adjusting for age and menopausal status.
Study suggests physiological testosterone levels may contribute to metabolic maintenance.
Focus on normal-weight women eliminates obesity-related metabolic biases.

Evaluate serum total testosterone levels in normal-weight women with glucose metabolism concerns.

Consider monitoring testosterone levels as part of metabolic health assessments.

Low testosterone levels may be associated with impaired glucose metabolism even in normal-weight women.

Normal-weight Japanese women.

Physiological testosterone levels may play a role in regulating glucose metabolism.

Incorporate testosterone level assessments in metabolic health evaluations for women.
Adjust for age and menopausal status when interpreting testosterone levels.

Clinical Scorecard: Exploring the Impact of Physiological Testosterone Levels on Glucose Metabolism in Normal-Weight Japanese Women: A Preliminary Study