Erratum for “Simultaneous Targeting of De Novo Pyrimidine Synthesis and ATR Enhances ATF4-Driven Apoptosis in TP53-Deficient Acute Lymphoblastic Leukemia”

Category	Detail
Condition	Acute Lymphoblastic Leukemia (ALL)
Key Mechanisms	Dual blockade of ATR and de novo pyrimidine synthesis promotes ATF4-mediated cell death.
Target Population	TP53-deficient Acute Lymphoblastic Leukemia patients
Care Setting	Hematology/Oncology

Dual blockade enhances apoptosis in TP53-deficient ALL.
ATF4 is a key mediator of cell death in this context.
Correction of ATR definition from Activating Transcription Factor 4 to Ataxia Telangiectasia and Rad3-related.

Patients with TP53-deficient Acute Lymphoblastic Leukemia

Targeting both ATR and pyrimidine synthesis may enhance treatment efficacy.

Clinical Scorecard: Erratum for “Simultaneous Targeting of De Novo Pyrimidine Synthesis and ATR Enhances ATF4-Driven Apoptosis in TP53-Deficient Acute Lymphoblastic Leukemia”