Clinical Scorecard: Bone Marrow Transplant: How Keck Medicine of USC Is Excelling in Survival Outcomes

At a Glance

Key Highlights

• USC Norris Blood and Marrow Transplant and Cell Therapy Program achieved highest +1 performance score from CIBMTR for six consecutive years.
• One-year allogeneic transplant survival rate of 86%, significantly exceeding national benchmarks.
• Early adoption of haploidentical transplant and novel immunosuppressive regimens contributed to improved outcomes.

Guideline-Based Recommendations

Diagnosis

• Careful patient selection to identify candidates who will benefit from transplantation and are not at excessive risk.
• Assessment of disease stage to ensure transplant appropriateness.

Management

• Use of haploidentical transplantation to expand donor availability, especially in racially and ethnically diverse populations.
• Application of advanced immunosuppressive regimens tailored to transplant type to reduce graft-versus-host disease.
• Multidisciplinary care involving specialists across organ systems to manage transplant-related complications.
• Provision of psychosocial, nutritional, and supportive care services integrated into transplant protocols.

Monitoring & Follow-up

• Long-term surveillance for graft-versus-host disease and infections.
• Monitoring for toxicity and organ impact from immunosuppressive therapies.

Risks

• Potential fatal complications from graft-versus-host disease and infections.
• Toxicity from strong immunosuppressive drugs affecting vital organs.

Patient & Prescribing Data

Adult patients undergoing allogeneic bone marrow transplant for hematologic malignancies or blood disorders.

Incorporation of haploidentical transplant protocols and novel immunosuppressive regimens has improved survival outcomes and expanded donor options.

Clinical Best Practices

• Early adoption and adaptation of haploidentical transplant techniques to increase donor availability.
• Implementation of innovative immunosuppressive regimens for both haploidentical and fully matched transplants.
• Multidisciplinary team approach including medical, surgical, psychosocial, nutritional, and pharmacy experts.
• Continuous application of latest scientific knowledge to clinical care and protocol development.
• Comprehensive patient support addressing medical and psychosocial needs throughout transplant journey.

References

• Center for International Blood and Marrow Transplant Research (CIBMTR) Performance Scoring
• Keck Medicine of USC - Blood and Marrow Transplant Program