Circulating microRNA molecular signatures converge with erythroid phenotypes and iron homeostasis in pediatric tic disorders
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By
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Ru Jia
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Tingting Zhu
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Xue Tian
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Simeng Wang
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Si Zhang
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Fei Fan
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Yaru Wang
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Yuxin Chai
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Zilin Chen
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Yuchen Hu
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Weifeng Li
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Fei Han
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May 4, 2026
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Clinical Scorecard: Circulating microRNA Profiles Correlate with Erythroid Characteristics and Iron Regulation in Children with Tic Disorders
At a Glance
| Category | Detail |
|---|
| Condition | Tic Disorders (TDs) |
| Key Mechanisms | Circulating microRNAs, erythroid phenotypes, iron homeostasis |
| Target Population | Children with Tic Disorders |
| Care Setting | Pediatric clinical settings |
Key Highlights
- hsa-miR-125b-5p and hsa-miR-23a-3p are significantly upregulated in TD children.
- TD children exhibit lower hemoglobin, MCV, serum ferritin, and transferrin levels.
- An integrated model combining miRNAs and erythroid parameters shows excellent diagnostic performance (AUC=0.977).
- Circulating miRNAs may serve as potential biomarkers for TD.
- Iron metabolism disturbances may be linked to tic disorder pathogenesis.
Guideline-Based Recommendations
Diagnosis
- Diagnosis based on clinical phenomenology and history as per DSM-5-TR.
Management
- Further research needed to establish objective biomarkers for clinical translation.
Monitoring & Follow-up
- Monitor erythroid parameters and iron metabolism indicators in TD children.
Risks
- Potential for functional impairment and reduced quality of life due to comorbidities.
Patient & Prescribing Data
Children diagnosed with Tic Disorders.
Investigate the role of circulating miRNAs and iron metabolism in treatment approaches.
Clinical Best Practices
- Utilize RT-qPCR for quantifying circulating miRNAs.
- Assess erythroid and iron metabolism parameters in conjunction with TD diagnosis.
References
