A Longitudinal Description of the Health-Related Quality of Life Among Individuals at High Risk After SARS-CoV-2 Infection: A Dutch Multicenter Observational Cohort Study - Scorecard - MDSpire

A Longitudinal Description of the Health-Related Quality of Life Among Individuals at High Risk After SARS-CoV-2 Infection: A Dutch Multicenter Observational Cohort Study

  • By

  • Magda Vergouwe

  • Emma Birnie

  • Sarah van Veelen

  • Jason J Biemond

  • Brent Appelman

  • Hessel Peters-Sengers

  • Godelieve J de Bree

  • Stephanie Popping

  • W Joost Wiersinga

  • on behalf of the

  • TURN-COVID Study Group

  • Matthijs R A Welkers

  • Frans J van Ittersum

  • Maarten F Schim van der Loeff

  • Marije K Bomers

  • Marie José Kersten

  • Mette D Hazenberg

  • Jarom Heijmans

  • Marc van der Valk

  • E Marleen Kemper

  • Marcel van den Berge

  • Heidi S M Ammerlaan

  • Marvin A H Berrevoets

  • Robbert J van Alphen

  • Renée A Douma

  • Eliane M S Leyten

  • Cees van Nieuwkoop

  • Rob J van Marum

  • Frits R Rosendaal

  • Mark G J de Boer

  • Astrid M L Oude Lashof

  • Marit G A van Vonderen

  • Jiri F P Wagenaar

  • Janneke E Stalenhoef

  • Frank van de Veerdonk

  • Robert-Jan Hassing

  • Robin Soetekouw

  • Hazra S Moeniralam

  • Frits van Osch

  • January 30, 2025

  • 0 min

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Clinical Scorecard: A Longitudinal Analysis of Health-Related Quality of Life in High-Risk Individuals Following SARS-CoV-2 Infection: Findings from a Dutch Multicenter Observational Cohort Study

At a Glance

CategoryDetail
ConditionPost–COVID-19 health-related quality of life (HRQoL) impairment in high-risk individuals
Key MechanismsSARS-CoV-2 infection leading to persistent symptoms and HRQoL decline, especially in immunocompromised and hospitalized patients
Target PopulationIndividuals at high risk for severe COVID-19, including solid organ transplant recipients, patients with hematologic malignancies, and those on immunosuppressive medication
Care SettingMulticenter observational cohort including hospitalized and nonhospitalized patients in Dutch hospitals

Key Highlights

  • Median HRQoL utility score declined significantly from 0.85 pre–COVID-19 to 0.81 at 12 months post–COVID-19 (P = .007).
  • Solid organ transplant recipients and patients requiring oxygen therapy are at increased risk for sustained HRQoL decline over 12 months.
  • Nearly half (45.3%) of employed participants reported COVID-19–related sick leave at 12 months, correlating with lower HRQoL scores.

Guideline-Based Recommendations

Diagnosis

  • Assess HRQoL using validated tools such as EQ-5D-5L at baseline and longitudinally post–COVID-19 in high-risk patients.
  • Identify high-risk individuals based on immunocompromising conditions and hospitalization status.

Management

  • Implement preventive approaches including vaccination and early therapeutic interventions (monoclonal antibodies, antivirals) in high-risk populations.
  • Monitor and address persistent symptoms such as fatigue, dyspnea, and cognitive impairment to improve HRQoL.

Monitoring & Follow-up

  • Conduct longitudinal follow-up at 3, 6, and 12 months post–COVID-19 to evaluate HRQoL and employment status.
  • Use mixed effects models to identify risk factors for HRQoL decline and guide individualized care.

Risks

  • High-risk patients, especially solid organ transplant recipients and those requiring oxygen therapy, have increased risk of long-term HRQoL impairment.
  • Persistent COVID-19 symptoms may lead to prolonged sick leave and reduced work capacity.

Patient & Prescribing Data

High-risk individuals with SARS-CoV-2 infection, including those treated with monoclonal antibodies or antiviral agents

Use of casirivimab-imdevimab, sotrovimab, and nirmatrelvir/ritonavir was part of routine care; however, HRQoL decline persists in some despite treatment, highlighting need for preventive strategies.

Clinical Best Practices

  • Regularly assess HRQoL using validated questionnaires (EQ-5D-5L, FSS, HADS) in high-risk COVID-19 patients.
  • Identify and monitor patients with solid organ transplants and those requiring oxygen therapy closely for HRQoL decline.
  • Support employed patients with COVID-19–related sick leave to address work capacity and rehabilitation needs.
  • Incorporate preventive measures including vaccination and timely antiviral therapy to mitigate severe disease and long-term HRQoL impact.

References

Original Source(s)

A Longitudinal Description of the Health-Related Quality of Life Among Individuals at High Risk After SARS-CoV-2 Infection: A Dutch Multicenter Observational Cohort Study

  • by Magda Vergouwe, Emma Birnie, Sarah van Veelen, Jason J Biemond, Brent Appelman, Hessel Peters-Sengers, Godelieve J de Bree, Stephanie Popping, W Joost Wiersinga, on behalf of the, TURN-COVID Study Group, Matthijs R A Welkers, Frans J van Ittersum, Maarten F Schim van der Loeff, Marije K Bomers, Marie José Kersten, Mette D Hazenberg, Jarom Heijmans, Marc van der Valk, E Marleen Kemper, Marcel van den Berge, Heidi S M Ammerlaan, Marvin A H Berrevoets, Robbert J van Alphen, Renée A Douma, Eliane M S Leyten, Cees van Nieuwkoop, Rob J van Marum, Frits R Rosendaal, Mark G J de Boer, Astrid M L Oude Lashof, Marit G A van Vonderen, Jiri F P Wagenaar, Janneke E Stalenhoef, Frank van de Veerdonk, Robert-Jan Hassing, Robin Soetekouw, Hazra S Moeniralam, Frits van Osch

  • January 30, 2025

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