Temperature and Heart Failure—The Exposure-Response Curve - Scorecard - MDSpire
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Temperature Exposure and Heart Failure: Understanding the Exposure–Response Relationship

  • By

  • Jagadeesh Puvvula

  • Sameed Ahmed M. Khatana

  • October 29, 2026

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Clinical Scorecard: Temperature Exposure and Heart Failure: Understanding the Exposure–Response Relationship

At a Glance

CategoryDetail
ConditionHeart failure (HF) hospitalization associated with ambient temperature exposure
Key MechanismsExtreme heat produces dehydration and reduces the capacity to preserve core body temperature; extreme cold narrows blood vessels, increasing blood pressure and the heart’s oxygen requirements. Both can result in cardiovascular stress and injury.
Target PopulationAdults aged 65 years and older, particularly those with HF
Care SettingContiguous US climate regions; evidence is based on HF hospitalizations among Medicare fee-for-service beneficiaries.

Key Highlights

  • In a 2007–2022 study, approximately 1 million adults aged 65 years and older experienced approximately 1.5 million HF hospitalizations. Compared with 75 °F, moderate cold at the 25th percentile was associated with 16% higher odds of hospitalization, and extreme cold at the 5th percentile with 12% higher odds.
  • Associations between moderate cold exposure and HF hospitalization varied across US climate regions.
  • Estimates for hot temperatures were imprecise and crossed the null, except in the South, where extreme heat was associated with 5% lower odds of HF hospitalization.
  • Daily mean temperature may not capture physiologically relevant heat stress; heat index or wet-bulb globe temperature may better represent combined environmental exposures.
  • The source discusses policy changes to support capacity building and adaptability, but the provided text ends before specifying interventions.

Guideline-Based Recommendations

Diagnosis

  • The article does not provide diagnostic criteria for HF.

Management

  • The provided source discusses policy changes to support capacity building and adaptability but does not specify management recommendations.

Monitoring & Follow-up

  • The article does not specify a clinical monitoring protocol.

Risks

  • Moderate cold at the 25th percentile was associated with increased odds of HF hospitalization; the source gives regional examples of 30 °F in West North Central and 54 °F in West.
  • Extreme-heat estimates for HF hospitalization were imprecise; death may compete with hospitalization and contribute to an apparently protective association.
  • Regional estimates using a fixed 75 °F reference temperature are not directly comparable because that reference represents different temperature percentiles across regions.

Patient & Prescribing Data

Adults aged 65 years and older; the study used a 50% random sample of Medicare fee-for-service beneficiaries. Approximately 1 million patients experienced approximately 1.5 million HF hospitalizations.

No medication prescribing data are reported. The provided source discusses temperature exposure and policy needs, but does not specify treatment or exposure-reduction interventions.

Clinical Best Practices

  • The article reports an association between moderate cold exposure and HF hospitalization among older adults; it does not provide clinical practice recommendations.
  • Consider that daily mean ambient temperature may not reflect personal exposure or physiologically relevant heat stress.
  • Interpret regional temperature associations cautiously when studies use a common reference temperature that represents different regional percentiles.

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