Temperature Exposure and Heart Failure: Understanding the Exposure–Response Relationship
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By
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Jagadeesh Puvvula
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Sameed Ahmed M. Khatana
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October 29, 2026
Clinical Scorecard: Temperature Exposure and Heart Failure: Understanding the Exposure–Response Relationship
At a Glance
| Category | Detail |
|---|---|
| Condition | Heart failure (HF) hospitalization associated with ambient temperature exposure |
| Key Mechanisms | Extreme heat produces dehydration and reduces the capacity to preserve core body temperature; extreme cold narrows blood vessels, increasing blood pressure and the heart’s oxygen requirements. Both can result in cardiovascular stress and injury. |
| Target Population | Adults aged 65 years and older, particularly those with HF |
| Care Setting | Contiguous US climate regions; evidence is based on HF hospitalizations among Medicare fee-for-service beneficiaries. |
Key Highlights
- In a 2007–2022 study, approximately 1 million adults aged 65 years and older experienced approximately 1.5 million HF hospitalizations. Compared with 75 °F, moderate cold at the 25th percentile was associated with 16% higher odds of hospitalization, and extreme cold at the 5th percentile with 12% higher odds.
- Associations between moderate cold exposure and HF hospitalization varied across US climate regions.
- Estimates for hot temperatures were imprecise and crossed the null, except in the South, where extreme heat was associated with 5% lower odds of HF hospitalization.
- Daily mean temperature may not capture physiologically relevant heat stress; heat index or wet-bulb globe temperature may better represent combined environmental exposures.
- The source discusses policy changes to support capacity building and adaptability, but the provided text ends before specifying interventions.
Guideline-Based Recommendations
Diagnosis
- The article does not provide diagnostic criteria for HF.
Management
- The provided source discusses policy changes to support capacity building and adaptability but does not specify management recommendations.
Monitoring & Follow-up
- The article does not specify a clinical monitoring protocol.
Risks
- Moderate cold at the 25th percentile was associated with increased odds of HF hospitalization; the source gives regional examples of 30 °F in West North Central and 54 °F in West.
- Extreme-heat estimates for HF hospitalization were imprecise; death may compete with hospitalization and contribute to an apparently protective association.
- Regional estimates using a fixed 75 °F reference temperature are not directly comparable because that reference represents different temperature percentiles across regions.
Patient & Prescribing Data
Adults aged 65 years and older; the study used a 50% random sample of Medicare fee-for-service beneficiaries. Approximately 1 million patients experienced approximately 1.5 million HF hospitalizations.
No medication prescribing data are reported. The provided source discusses temperature exposure and policy needs, but does not specify treatment or exposure-reduction interventions.
Clinical Best Practices
- The article reports an association between moderate cold exposure and HF hospitalization among older adults; it does not provide clinical practice recommendations.
- Consider that daily mean ambient temperature may not reflect personal exposure or physiologically relevant heat stress.
- Interpret regional temperature associations cautiously when studies use a common reference temperature that represents different regional percentiles.
Related Resources & Content
Based on findings from:
Temperature and Heart Failure—The Exposure-Response Curve
Jagadeesh Puvvula, Sameed Ahmed M. Khatana. Jama Network Open, 2026.
https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2855952
This content is an AI-generated, fully rewritten summary based on a published scholarly article. It does not reproduce the original text and is not a substitute for the original publication. Readers are encouraged to consult the source for full context, data, and methodology.