Cerebrospinal fluid proteomics identifies calcyphosine and follistatin-like 1 as exploratory candidate proteins of interest in hydrocephalus - Scorecard - MDSpire

Cerebrospinal fluid proteomics identifies calcyphosine and follistatin-like 1 as exploratory candidate proteins of interest in hydrocephalus

  • By

  • Hao Han

  • Xun Xie

  • Mingchen Xie

  • Yahui Zhang

  • Jianhua Cheng

  • Jian Xu

  • May 29, 2026

  • 0 min

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Clinical Scorecard: Cerebrospinal Fluid Proteomic Analysis Reveals Calcyphosine and Follistatin-like 1 as Potential Biomarkers in Hydrocephalus

At a Glance

CategoryDetail
Condition
Key MechanismsDistinct protein-abundance patterns in cerebrospinal fluid (CSF) associated with post-hemorrhagic hydrocephalus (PHH) and idiopathic normal pressure hydrocephalus (iNPH).
Target Population
Care Setting

Key Highlights

  • PHH shows elevated calcyphosine (CAPS) levels and reduced neuronal maintenance proteins.
  • iNPH exhibits increased follistatin-like 1 (FSTL1) levels with decreased synaptic and growth-factor signaling proteins.
  • Distinct CSF proteomic signatures identified for PHH and iNPH.

Guideline-Based Recommendations

Diagnosis

  • Differential diagnosis of hydrocephalus types based on CSF proteomic profiles.

Management

  • CSF diversion by shunting remains the mainstay of treatment for hydrocephalus.

Monitoring & Follow-up

  • Monitoring of CSF protein levels may provide insights into disease progression.

Risks

  • Complications from shunting include infection, obstruction, and overdrainage.

Patient & Prescribing Data

Patients with post-hemorrhagic hydrocephalus and idiopathic normal pressure hydrocephalus.

No pharmacological therapy has been proven to halt or reverse the processes in hydrocephalus.

Clinical Best Practices

  • Utilize proteomic analysis for better understanding of hydrocephalus pathobiology.

Related Resources & Content

Original Source(s)

Cerebrospinal fluid proteomics identifies calcyphosine and follistatin-like 1 as exploratory candidate proteins of interest in hydrocephalus

  • by Hao Han, Xun Xie, Mingchen Xie, Yahui Zhang, Jianhua Cheng, Jian Xu

  • May 29, 2026

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