Emapunil attenuates ulcerative colitis by suppressing Z-DNA binding protein 1 driven pyroptosis and pro-inflammatory polarization in macrophages - Scorecard - MDSpire

Emapunil attenuates ulcerative colitis by suppressing Z-DNA binding protein 1 driven pyroptosis and pro-inflammatory polarization in macrophages

  • By

  • Shenghao Xv

  • Jie Hao

  • Sanhua Deng

  • Zhengyin Zhang

  • Runshu Wang

  • Jianbin Yin

  • Peisheng Chen

  • Fengjian He

  • Qianqian Peng

  • Fang Xie

  • Erwei Sun

  • Shimin Zheng

  • May 26, 2026

  • 0 min

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Clinical Scorecard: Emapunil Reduces Ulcerative Colitis Severity by Inhibiting Z-DNA Binding Protein 1-Mediated Pyroptosis and Macrophage Inflammatory Polarization

At a Glance

CategoryDetail
Condition
Key Mechanisms
Target Population
Care SettingClinical management of inflammatory bowel disease, specifically for ulcerative colitis.

Key Highlights

  • Emapunil targets ZBP1 to modulate macrophage activity, providing a novel therapeutic approach.

Guideline-Based Recommendations

Diagnosis

    Management

      Monitoring & Follow-up

      • Monitor ZBP1 levels and macrophage activity in patients undergoing treatment, ideally through regular blood tests or tissue biopsies.

      Risks

        Patient & Prescribing Data

        Patients diagnosed with Ulcerative Colitis.

        Emapunil may provide a novel mechanism for managing UC by targeting ZBP1.

        Clinical Best Practices

        • Utilize Emapunil in conjunction with existing therapies such as biologics or corticosteroids for enhanced outcomes.

        Related Resources & Content

        Original Source(s)

        Emapunil attenuates ulcerative colitis by suppressing Z-DNA binding protein 1 driven pyroptosis and pro-inflammatory polarization in macrophages

        • by Shenghao Xv, Jie Hao, Sanhua Deng, Zhengyin Zhang, Runshu Wang, Jianbin Yin, Peisheng Chen, Fengjian He, Qianqian Peng, Fang Xie, Erwei Sun, Shimin Zheng

        • May 26, 2026

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