Evaluation of eradication efficacy and optimization strategies for Helicobacter pylori infection based on real-world data: a multivariable retrospective study - Scorecard - MDSpire
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Assessment of Treatment Effectiveness and Improvement Approaches for Helicobacter pylori Infection Utilizing Real-World Evidence: A Retrospective Multivariable Analysis

  • By

  • Ziqi He

  • Linde He

  • Yaliu Qu

  • Yiting Zheng

  • Leyi Dou

  • Shijuan Luo

  • Zhenhao Ye

  • Chaoyuan Huang

  • July 1, 2026

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Clinical Scorecard: Assessment of Treatment Effectiveness and Improvement Approaches for Helicobacter pylori Infection Utilizing Real-World Evidence: A Retrospective Multivariable Analysis

At a Glance

CategoryDetail
ConditionHelicobacter pylori infection
Key MechanismsEradication efficacy varies among treatment regimens; prescription appropriateness impacts outcomes.
Target PopulationPatients diagnosed with H. pylori infection
Care SettingSingle-center retrospective study

Key Highlights

  • Overall ITT eradication rate was 79.04%; PP rate was 90.23%.
  • Quadruple therapy showed the highest eradication rates (ITT: 81.42%; PP: 93.76%).
  • Prescription appropriateness significantly affected eradication success in quadruple therapy.
  • Female patients had higher eradication success in quadruple therapy.
  • Older patients and those using traditional Chinese medicine demonstrated better follow-up compliance.

Guideline-Based Recommendations

Diagnosis

  • Diagnosis confirmed by a positive 13C-urea breath test or histopathological examination.

Management

  • Bismuth-containing quadruple therapy should be the first-line treatment.

Monitoring & Follow-up

  • Follow-up adherence should be assessed post-treatment.

Risks

  • Inappropriate prescribing practices may reduce eradication effectiveness.

Patient & Prescribing Data

897 patients with confirmed H. pylori infection.

Eradication rates vary significantly based on treatment regimen and prescription appropriateness.

Clinical Best Practices

  • Prioritize guideline-recommended regimens for H. pylori treatment.
  • Assess and ensure appropriate dosing in treatment regimens.

Related Resources & Content

Original Source(s)

Evaluation of eradication efficacy and optimization strategies for Helicobacter pylori infection based on real-world data: a multivariable retrospective study

  • by Ziqi He, Linde He, Yaliu Qu, Yiting Zheng, Leyi Dou, Shijuan Luo, Zhenhao Ye, Chaoyuan Huang

  • July 1, 2026

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