Comparative Effectiveness of Conventional Treatment and Acoustic Therapy for Acute Tinnitus in Patients with Idiopathic Sudden Sensorineural Hearing Loss: A Randomized Controlled Study - Scorecard - MDSpire

Comparative Effectiveness of Conventional Treatment and Acoustic Therapy for Acute Tinnitus in Patients with Idiopathic Sudden Sensorineural Hearing Loss: A Randomized Controlled Study

  • By

  • Xinyi Wang

  • Ke Qiu

  • Yuyang Zhang

  • Sen Yang

  • Yanhong Xu

  • Xiaosong Mu

  • Yaxin Luo

  • Wendu Pang

  • Jiangnan Han

  • Chunhong Hu

  • Jia Chen

  • Ning Ma

  • Wen He

  • Wei Dai

  • Yang Zou

  • Lingfeng Xiong

  • Hongchang Chen

  • Weifeng Chen

  • Dengyun Zhang

  • Guanghui Zhang

  • Zhen Hu

  • Lintong Dai

  • Xiaohai Liu

  • Bingcai He

  • Xiaobing Pu

  • Wei Xu

  • Jianjun Ren

  • Yu Zhao

  • November 28, 2025

  • 0 min

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Clinical Scorecard: Comparative Effectiveness of Conventional Treatment and Acoustic Therapy for Acute Tinnitus in Patients with Idiopathic Sudden Sensorineural Hearing Loss: A Randomized Controlled Study

At a Glance

CategoryDetail
ConditionIdiopathic Sudden Sensorineural Hearing Loss (ISSHL) with acute tinnitus
Key MechanismsSystemic steroids and personalized acoustic therapy (AT) targeting both peripheral and central mechanisms of tinnitus
Target PopulationAdults aged 18-65 with ISSHL and bothersome acute tinnitus
Care SettingMulti-center, tertiary hospitals in Sichuan province, China

Key Highlights

  • ISSHL affects approximately 10–27 cases per 100,000 people annually
  • 90% of ISSHL patients experience concurrent tinnitus
  • Systemic steroids are the first-line treatment for ISSHL
  • Personalized AT aims to disrupt tinnitus percepts through sound therapy
  • Limited evidence exists on the efficacy of AT for ISSHL-related tinnitus

Guideline-Based Recommendations

Diagnosis

  • Confirm ISSHL through pure-tone audiometry showing a loss of 20 dB or more at two contiguous frequencies

Management

  • First-line treatment includes systemic steroids; combination with thrombolytics is recommended in Chinese guidelines

Monitoring & Follow-up

  • Conduct regular audiometric assessments during the treatment and follow-up period

Risks

  • Potential contraindications include allergies to treatment components and severe comorbidities

Patient & Prescribing Data

Adults aged 18-65 with recent onset of ISSHL and acute tinnitus

Combination of systemic steroids and personalized AT may improve tinnitus outcomes

Clinical Best Practices

  • Implement a multi-disciplinary approach for managing ISSHL and associated tinnitus
  • Ensure thorough pre-enrollment screening to identify eligible participants
  • Utilize randomization and blinding to minimize bias in clinical trials

References

Original Source(s)

Comparative Effectiveness of Conventional Treatment and Acoustic Therapy for Acute Tinnitus in Patients with Idiopathic Sudden Sensorineural Hearing Loss: A Randomized Controlled Study

  • by Xinyi Wang, Ke Qiu, Yuyang Zhang, Sen Yang, Yanhong Xu, Xiaosong Mu, Yaxin Luo, Wendu Pang, Jiangnan Han, Chunhong Hu, Jia Chen, Ning Ma, Wen He, Wei Dai, Yang Zou, Lingfeng Xiong, Hongchang Chen, Weifeng Chen, Dengyun Zhang, Guanghui Zhang, Zhen Hu, Lintong Dai, Xiaohai Liu, Bingcai He, Xiaobing Pu, Wei Xu, Jianjun Ren, Yu Zhao

  • November 28, 2025

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