A screening model for advanced colorectal neoplasia based on tumor markers and inflammatory indices: a retrospective study with an online risk calculator - Scorecard - MDSpire

A screening model for advanced colorectal neoplasia based on tumor markers and inflammatory indices: a retrospective study with an online risk calculator

  • By

  • Zhang, Chang

  • Jin, Lei

  • Wu, Shihao

  • Lu, Liang

  • Jin, Shui

  • June 22, 2026

  • 0 min

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Clinical Scorecard: Development and Validation of a Noninvasive Screening Model for Advanced Colorectal Neoplasia Using Tumor Markers and Inflammatory Indices: A Retrospective Analysis with an Online Risk Assessment Tool

At a Glance

CategoryDetail
ConditionAdvanced Colorectal Neoplasia
Key MechanismsUtilization of blood tumor markers and inflammatory indices for screening
Target PopulationPatients undergoing colonoscopy with preoperative blood test results
Care SettingClinical practice for noninvasive screening

Key Highlights

  • 1,290 patients included in the study
  • 210 patients diagnosed with advanced colorectal neoplasms
  • Independent predictors identified: CEA, SII, NLR, ALB, PLR
  • XGBoost model achieved AUC of 0.956
  • Online calculator developed for individual risk assessment

Guideline-Based Recommendations

Diagnosis

  • Screening for advanced colorectal neoplasia using identified blood markers

Management

  • Utilization of machine learning models to assess risk

Monitoring & Follow-up

  • Regular evaluation of blood markers in patients at risk

Risks

  • Potential for misclassification without proper screening

Patient & Prescribing Data

Patients with indications for colonoscopy and preoperative blood tests

Noninvasive screening model can guide further diagnostic procedures

Clinical Best Practices

  • Incorporate blood tumor markers in routine screening protocols
  • Utilize online risk assessment tools in clinical settings
  • Regularly update predictive models based on new data

Related Resources & Content

    Original Source(s)

    A screening model for advanced colorectal neoplasia based on tumor markers and inflammatory indices: a retrospective study with an online risk calculator

    • by Zhang, Chang , Jin, Lei , Wu, Shihao , Lu, Liang , Jin, Shui

    • June 22, 2026

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