A Case of Amphotericin B-Resistant Cryptococcus laurentii Meningitis Complicated by Pulmonary Tuberculosis in a Patient with Pauci-Immune Crescentic Glomerulonephritis Due to MPO ANCA Vasculitis in Nepal - Scorecard - MDSpire
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A Case of Amphotericin B-Resistant Cryptococcus laurentii Meningitis Complicated by Pulmonary Tuberculosis in a Patient with Pauci-Immune Crescentic Glomerulonephritis Due to MPO ANCA Vasculitis in Nepal
Clinical Scorecard: A Case of Amphotericin B-Resistant Cryptococcus laurentii Meningitis Complicated by Pulmonary Tuberculosis in a Patient with Pauci-Immune Crescentic Glomerulonephritis Due to MPO ANCA Vasculitis in Nepal
At a Glance
Category
Detail
Condition
Key Mechanisms
Target Population
Young male patients with ANCA vasculitis undergoing immunosuppressive therapy
Care Setting
Key Highlights
Rare case of Cryptococcus laurentii meningitis resistant to Amphotericin B in a young male
Co-occurrence of pulmonary tuberculosis complicating the clinical picture
Guideline-Based Recommendations
Diagnosis
Management
Initiate antifungal therapy with liposomal Amphotericin B (4 mg/kg) and fluconazole (800 mg/day)
Adjust antifungal treatment based on susceptibility testing
Monitoring & Follow-up
Risks
Patient & Prescribing Data
17-year-old male with pauci-immune crescentic glomerulonephritis
Clinical Best Practices
Consider prophylactic treatment for opportunistic infections in high-risk patients
Utilize susceptibility testing to guide antifungal therapy
Educate patients on signs of infection during immunosuppressive therapy
Recommend follow-up imaging or tests post-treatment
