Spectral CT iodine quantification for peritoneal metastasis burden and resectability prediction in ovarian cancer: a retrospective cohort study

Category	Detail
Condition	Ovarian Cancer with Peritoneal Metastasis
Key Mechanisms	Spectral CT iodine quantification for assessing tumor vascularity and predicting surgical resectability.
Target Population	Women aged 18–75 years with newly diagnosed, treatment-naïve ovarian cancer.
Care Setting	Gynecologic Oncology Center, single-center retrospective study.

Iodine-based parameters correlate strongly with intraoperative Peritoneal Cancer Index (PCI).
Normalized iodine concentration (NIC) shows potential as a predictive marker for R0 resection.
A NIC cutoff value of ≤0.55 yields high sensitivity and negative predictive value for surgical outcomes.
Combined model of NIC, PCI, and CA-125 enhances predictive accuracy for surgical resectability.
Spectral CT offers objective metrics that may improve preoperative assessment of peritoneal metastasis.

Utilize spectral CT for quantitative assessment of peritoneal metastasis burden.

Regularly assess iodine concentration metrics in conjunction with clinical evaluations.

145 ovarian cancer patients undergoing preoperative spectral CT and cytoreductive surgery.

Iodine quantification may guide surgical decision-making and reduce unnecessary exploratory surgeries.

Incorporate spectral CT iodine quantification into preoperative assessment protocols.
Use NIC as a stratification tool for predicting surgical outcomes.
Ensure adherence to imaging protocols to minimize radiation exposure.

Clinical Scorecard: Iodine Quantification via Spectral CT for Assessing Peritoneal Metastasis Load and Surgical Resectability in Ovarian Cancer: A Retrospective Analysis