Reversing Epigenetic Changes in Skin Aging to Enhance Longevity Across Various Ethnicities and Skin Types with a Dihydromyricetin-Enriched Serum: Findings from a Prospective Cohort Investigation - Scorecard - MDSpire
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Reversing Epigenetic Changes in Skin Aging to Enhance Longevity Across Various Ethnicities and Skin Types with a Dihydromyricetin-Enriched Serum: Findings from a Prospective Cohort Investigation

  • By

  • Minyue Qi

  • Paula Pitta

  • Katrin Wegner

  • Boris Kristof

  • Yan Feng

  • Günter Raddatz

  • Manuel Rodríguez-Paredes

  • Julia Gallinger

  • Rungsima Wanitphakdeedecha

  • Marc Winnefeld

  • Lilia Guadanhim

  • Cheri Frey

  • Frank Lyko

  • Cassandra Falckenhayn

  • Elke Grönniger

  • April 25, 2026

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Clinical Scorecard: Reversing Epigenetic Changes in Skin Aging to Enhance Longevity Across Various Ethnicities and Skin Types with a Dihydromyricetin-Enriched Serum: Findings from a Prospective Cohort Investigation

At a Glance

CategoryDetail
ConditionSkin Aging
Key MechanismsEpigenetic alterations, particularly DNA methylation, are primary hallmarks of skin aging.
Target PopulationDiverse ethnicities and phototypes aged 24 to 70 years.
Care SettingClinical research settings.

Key Highlights

  • Epigenetic aging signatures are conserved across ethnicities.
  • Dihydromyricetin (DHM) reverses biological skin age.
  • Visible and structural signs of aging improve with DHM application.
  • Study includes participants from diverse ethnic backgrounds.
  • Epigenetic rejuvenation is proposed as a strategy for skin longevity.

Guideline-Based Recommendations

Diagnosis

  • Utilize DNA methylation patterns as biomarkers for biological skin age.

Management

  • Apply topical formulations containing dihydromyricetin to address epigenetic alterations.

Monitoring & Follow-up

  • Assess changes in skin aging phenotypes through epigenetic analysis.

Risks

  • Consider individual skin type and ethnicity when applying interventions.

Patient & Prescribing Data

Participants aged 40-70 from diverse Brazilian backgrounds.

Dihydromyricetin shows potential for improving skin aging across various ethnicities.

Clinical Best Practices

  • Incorporate diverse ethnicities in skin aging research.
  • Focus on epigenetic mechanisms when developing anti-aging treatments.
  • Ensure ethical compliance in clinical studies involving human subjects.

Related Resources & Content

Original Source(s)

Reversing Epigenetic Changes in Skin Aging to Enhance Longevity Across Various Ethnicities and Skin Types with a Dihydromyricetin-Enriched Serum: Findings from a Prospective Cohort Investigation

  • by Minyue Qi, Paula Pitta, Katrin Wegner, Boris Kristof, Yan Feng, Günter Raddatz, Manuel Rodríguez-Paredes, Julia Gallinger, Rungsima Wanitphakdeedecha, Marc Winnefeld, Lilia Guadanhim, Cheri Frey, Frank Lyko, Cassandra Falckenhayn, Elke Grönniger

  • April 25, 2026

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