Codonopsis pilosula polysaccharide attenuates the inflammatory response in macrophages induced by Brucella abortus outer membrane protein 19 via regulating ATP2A1 to modulate cell adhesion and calcium signaling
By
Xuxu Wang
Zhiyong Zhou
Nan Zhang
Ziying Zhang
Xingyue Qi
Xingguang Zhang
Zhiguo Gong
Wuzhi Zhong
Kun Liu
Yuan Shen
June 2, 2026
Clinical Scorecard: Polysaccharides from Codonopsis pilosula Reduce Macrophage Inflammation Triggered by Brucella abortus Outer Membrane Protein 19 Through ATP2A1 Regulation Affecting Cell Adhesion and Calcium Signaling
At a Glance
Category Detail
Condition Brucellosis Key Mechanisms Inhibition of inflammatory signaling, enhancement of macrophage phagocytosis, modulation of cytokine profile Target Population Individuals infected with Brucella species Care Setting Clinical and research settings focusing on infectious diseases
Key Highlights
CPPS significantly alleviated tissue damage in vivo. CPPS downregulated pro-inflammatory cytokines TNF-α and IL-6 while increasing IL-10. ATP2A1 was identified as a key gene regulated by CPPS. CPPS inhibited SYK/FAK/AKT phosphorylation and PKC activation. CPPS reduced intracellular calcium ion concentration. Guideline-Based Recommendations
Diagnosis
Brucellosis is diagnosed based on clinical symptoms and serological tests. Management
CPPS may serve as a therapeutic agent to modulate inflammation in brucellosis. Monitoring & Follow-up
Monitor cytokine levels and inflammatory markers in patients with brucellosis. Risks
Brucellosis can lead to chronic complications if not treated effectively. Patient & Prescribing Data
Patients with brucellosis or at risk of Brucella infection
CPPS may enhance macrophage function and reduce inflammation.
Clinical Best Practices
Consider CPPS as an adjunct therapy in managing brucellosis. Monitor immune response and inflammatory markers during treatment. Related Resources & Content
