Comparison of hybrid surgeries for the treatment of three-level cervical degenerative disease: a systematic review and network meta-analysis - Scorecard - MDSpire

Comparison of hybrid surgeries for the treatment of three-level cervical degenerative disease: a systematic review and network meta-analysis

  • By

  • Jiyuan Liao

  • Yuchen Duan

  • Yunfei Lu

  • Wenjie Liu

  • July 8, 2026

  • 0 min

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Clinical Scorecard: Evaluation of Hybrid Surgical Approaches for Managing Three-Level Cervical Degenerative Disease: A Systematic Review and Network Meta-Analysis

At a Glance

CategoryDetail
ConditionCervical Degenerative Disease (CDD)
Key MechanismsDegenerative pathological changes in the cervical spine leading to compression of the spinal cord, nerve roots, or vertebral artery.
Target PopulationPatients with three-level cervical degenerative disease who have not improved with conservative therapy.
Care SettingSurgical management of multisegmental cervical degenerative disease.

Key Highlights

  • Hybrid surgery (HS1 and HS2) preserves C2-7 range of motion better than ACDF.
  • HS1 (1-level TDR with 2-level ACDF) shows lower Neck Disability Index compared to ACDF.
  • No significant difference in range of motion between HS1 and HS2.
  • Incidence of adjacent segment degeneration (ASD) is similar across HS1, HS2, and ACDF.

Guideline-Based Recommendations

Diagnosis

  • Confirm three-level CDD through CT or MRI.

Management

  • Consider hybrid surgery (HS1 or HS2) or ACDF based on the severity of degeneration.

Monitoring & Follow-up

  • Assess clinical and radiological outcomes post-surgery.

Risks

  • Monitor for complications such as ASD and revision surgery rates.

Patient & Prescribing Data

Patients with three-level CDD who have failed conservative treatment.

HS1 and HS2 may offer better preservation of cervical motion compared to ACDF.

Clinical Best Practices

  • Utilize hybrid surgical approaches for targeted treatment of multisegmental CDD.
  • Evaluate the degree of degeneration to select appropriate surgical method.

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