Clinical Scorecard: Effects of a High-Fat Western Diet on Disease Progression and Gut Microbiome Alterations in Eµ-TCL1 Mouse Model of Chronic Lymphocytic Leukemia
At a Glance
Category
Detail
Condition
Chronic Lymphocytic Leukemia (CLL)
Key Mechanisms
Impact of high-fat diet on gut microbiome and disease progression
Target Population
Eµ-TCL1 murine model of CLL
Care Setting
Diet modulation study
Key Highlights
High-fat diet led to significantly shorter survival in mice compared to standard chow diet.
Increased splenic involvement by CLL observed in high-fat diet-fed mice.
High-fat diet caused immediate and profound changes in gut microbiome composition.
Higher disease burden correlated with reduced alpha diversity in gut microbiome.
Sustained increase in Akkermansia muciniphila and Bacteroidetes thetaiotaomicron in high-fat diet-fed mice.
Guideline-Based Recommendations
Diagnosis
Management
Monitoring & Follow-up
Risks
Patient & Prescribing Data
Not applicable, study conducted in murine model.
High-fat diets may negatively impact gut microbiome and CLL outcomes.
Clinical Best Practices
Consider dietary influences on gut microbiome in CLL pathogenesis.
Monitor changes in gut microbiome diversity in relation to disease progression.
by Sydney A. Skupa, Jordan B. Hernandez, Audrey L. Smith, Erin M. Drengler, Jayesh Rai, Jianmin Pan, Anand K. Seth, Shesh N. Rai, Jonathan B. Clayton, Christopher R. D’Angelo, Dalia El-Gamal
