25HC regulates the polarization of CD163+ macrophages in the immune microenvironment of triple-negative breast cancer through the interferon pathway - Scorecard - MDSpire

25HC regulates the polarization of CD163+ macrophages in the immune microenvironment of triple-negative breast cancer through the interferon pathway

  • By

  • Hongmei Zheng

  • Wenqin Huang

  • Panshi Zhang

  • Sudhanshu Bhushan

  • Xinhong Wu

  • Yalong Yang

  • May 28, 2026

  • 0 min

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Clinical Scorecard: 25-Hydroxycholesterol Modulates CD163+ Macrophage Polarization in the Immune Microenvironment of Triple-Negative Breast Cancer via the Interferon Signaling Pathway

At a Glance

CategoryDetail
ConditionTriple-Negative Breast Cancer (TNBC)
Key MechanismsAberrant activation of the interferon regulatory factor 7–cholesterol-25-hydroxylase–25HC axis regulates macrophage polarization.
Target PopulationPatients with Triple-Negative Breast Cancer (TNBC)
Care SettingOncology and research settings focusing on breast cancer

Key Highlights

  • 25-hydroxycholesterol (25HC) identified as a key regulator of macrophage polarization in TNBC.
  • The study delineates the link between dysregulated 25HC metabolism and macrophage polarization.
  • Unique immune landscape of TNBC characterized by higher levels of tumor-infiltrating lymphocytes (TILs).
  • The role of tumor-associated macrophages (TAMs) in TNBC is complex and context-dependent.

Guideline-Based Recommendations

Diagnosis

  • Utilize multiplex fluorescence immunohistochemistry to profile the immune microenvironment in TNBC.

Management

  • Investigate therapeutic strategies targeting the 25HC metabolic pathway in TNBC.

Monitoring & Follow-up

  • Monitor macrophage polarization states in the tumor microenvironment.

Risks

  • Consider the implications of macrophage polarization on tumor progression and treatment resistance.

Patient & Prescribing Data

Women diagnosed with Triple-Negative Breast Cancer (TNBC).

Targeting the 25HC pathway may offer new therapeutic avenues for TNBC.

Clinical Best Practices

  • Integrate bioinformatic analyses with experimental validation to understand immune mechanisms in TNBC.
  • Consider the immune context when evaluating treatment responses in TNBC.

Related Resources & Content

Original Source(s)

25HC regulates the polarization of CD163+ macrophages in the immune microenvironment of triple-negative breast cancer through the interferon pathway

  • by Hongmei Zheng, Wenqin Huang, Panshi Zhang, Sudhanshu Bhushan, Xinhong Wu, Yalong Yang

  • May 28, 2026

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