Spatial immune archetypes in gastric and colorectal cancer: a proposed conceptual framework for immunotherapy resistance and therapeutic remodeling - Scorecard - MDSpire
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Spatial immune archetypes in gastric and colorectal cancer: a proposed conceptual framework for immunotherapy resistance and therapeutic remodeling
Clinical Scorecard: Immune Spatial Patterns in Gastric and Colorectal Cancers: A Conceptual Framework Addressing Resistance to Immunotherapy and Opportunities for Therapeutic Modification
At a Glance
Category
Detail
Condition
Key Mechanisms
Spatial immune archetypes govern immune exclusion, metabolic suppression, local activation, and epithelial-immune contact.
Target Population
Care Setting
Key Highlights
Guideline-Based Recommendations
Diagnosis
Utilize spatial transcriptomics and multiplexed proteomics for better understanding of immune microenvironments.
Management
Consider archetype-guided strategies for microenvironment remodeling in MSS/pMMR cancers.
Monitoring & Follow-up
Assess spatial immune archetypes to predict immunotherapy responses.
Risks
Recognize that standard profiling may not capture the complexity of immune evasion mechanisms.
Patient & Prescribing Data
Current therapies show limited efficacy; spatial immune architecture may provide new targets.
