Independent prognostic value of the triglyceride–glucose index and its incremental predictive contribution beyond traditional risk markers in acute heart failure: a retrospective cohort study - Scorecard - MDSpire
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Independent prognostic value of the triglyceride–glucose index and its incremental predictive contribution beyond traditional risk markers in acute heart failure: a retrospective cohort study
Clinical Scorecard: Prognostic Significance of the Triglyceride–Glucose Index in Acute Heart Failure: A Retrospective Cohort Analysis of Its Added Predictive Value Beyond Conventional Risk Factors
At a Glance
Category
Detail
Condition
Acute Heart Failure
Key Mechanisms
Triglyceride–glucose (TyG) index as a marker of insulin resistance
Target Population
Patients hospitalized with acute heart failure
Care Setting
Single-center hospital setting
Key Highlights
Higher TyG levels associated with increased risk of cardiovascular death or rehospitalization (HR = 1.74)
Patients in the highest TyG quartile had a significantly higher risk compared to the lowest quartile (HR = 2.17)
TyG index demonstrated comparable discriminative ability to NT-proBNP
Combined model of TyG and NT-proBNP improved risk prediction
Guideline-Based Recommendations
Diagnosis
Diagnosis of acute heart failure based on clinical symptoms, imaging evidence, and NT-proBNP thresholds
Management
Utilization of NT-proBNP for prognostic assessment in acute heart failure
Monitoring & Follow-up
Regular assessment of TyG index alongside traditional biomarkers for risk stratification
Risks
Increased risk of rehospitalization and mortality in patients with elevated TyG levels
Patient & Prescribing Data
712 patients hospitalized with acute heart failure
Inclusion of TyG index may enhance risk stratification and management strategies
Clinical Best Practices
Incorporate TyG index in risk assessment protocols for acute heart failure
Monitor metabolic markers in conjunction with traditional biomarkers
