Clinical efficacy of repetitive transcranial magnetic stimulation combined with electroacupuncture at Baliao points for functional constipation: a retrospective study - Scorecard - MDSpire

Efficacy of Combining Repetitive Transcranial Magnetic Stimulation with Electroacupuncture at Baliao Points in Treating Functional Constipation: A Retrospective Analysis

  • By

  • Lijie Gao

  • Yabei Shen

  • Shicai Huang

  • Xiangmei Gu

  • Mengjie Wang

  • Dong Fang

  • Sufen Han

  • July 21, 2026

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Clinical Scorecard: Efficacy of Combining Repetitive Transcranial Magnetic Stimulation with Electroacupuncture at Baliao Points in Treating Functional Constipation: A Retrospective Analysis

At a Glance

CategoryDetail
ConditionFunctional Constipation
Key MechanismsInvolves abnormal colonic motility, visceral sensory dysfunction, and dysregulation of the brain-gut axis; rTMS modulates cortical excitability while EA stimulates sacral nerve roots.
Target PopulationPatients aged 18–70 years diagnosed with functional constipation according to Rome IV criteria.
Care SettingRetrospective cohort study conducted in a hospital setting.

Key Highlights

  • rTMS combined with EA significantly improved weekly complete spontaneous bowel movements (CSBMs) compared to EA alone.
  • Significant improvements in Patient Assessment of Constipation Symptoms (PAC-SYM) and quality of life metrics were observed.
  • A large response (≥3 CSBMs/week increase) was more frequent in the combined treatment group.
  • Adverse events were mild and comparable between both treatment groups.
  • Findings are exploratory and require confirmation in randomized controlled trials.

Guideline-Based Recommendations

Diagnosis

  • Functional constipation diagnosed according to Rome IV criteria.

Management

  • Consider combining rTMS with electroacupuncture for improved treatment outcomes in functional constipation.

Monitoring & Follow-up

  • Monitor weekly complete spontaneous bowel movements and symptom severity using PAC-SYM.

Risks

  • Mild adverse events reported; no significant differences in adverse event rates between treatment groups.

Patient & Prescribing Data

Patients with functional constipation who have failed at least one prior conventional treatment.

Combination therapy may yield better outcomes than electroacupuncture alone.

Clinical Best Practices

  • Utilize a multimodal approach targeting both central and peripheral mechanisms in treating functional constipation.
  • Incorporate patient preferences in treatment decisions.

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