Aspirin is associated with improved outcomes in sepsis patients with atrial fibrillation: an analysis of the MIMIC-IV and eICU-CRD databases - Scorecard - MDSpire

Aspirin is associated with improved outcomes in sepsis patients with atrial fibrillation: an analysis of the MIMIC-IV and eICU-CRD databases

  • By

  • Fangchao Chen

  • Yufeng Zhong

  • Dianyang Wang

  • Qiuyin Wei

  • Rui Su

  • Hongfei Ge

  • Wencai Wei

  • Wei Wang

  • May 26, 2026

  • 0 min

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Clinical Scorecard: The Impact of Aspirin on Clinical Outcomes in Sepsis Patients with Atrial Fibrillation: Insights from MIMIC-IV and eICU-CRD Databases

At a Glance

CategoryDetail
Condition
Key MechanismsDysregulated inflammation, endothelial injury, platelet activation, immunothrombosis
Target Population
Care Setting

Key Highlights

  • In MIMIC-IV, hazard ratio for 30-day mortality with aspirin was 0.624 (95% CI: 0.547–0.712; P < 0.001).
  • In eICU-CRD, early aspirin exposure linked to lower in-hospital mortality (HR: 0.732, 95% CI: 0.559–0.959; P = 0.024).

Guideline-Based Recommendations

Diagnosis

    Management

    • Consider early aspirin exposure in sepsis patients with atrial fibrillation.

    Monitoring & Follow-up

      Risks

        Patient & Prescribing Data

        Aspirin may have antiplatelet and anti-inflammatory effects.

        Clinical Best Practices

          Related Resources & Content

          Original Source(s)

          Aspirin is associated with improved outcomes in sepsis patients with atrial fibrillation: an analysis of the MIMIC-IV and eICU-CRD databases

          • by Fangchao Chen, Yufeng Zhong, Dianyang Wang, Qiuyin Wei, Rui Su, Hongfei Ge, Wencai Wei, Wei Wang

          • May 26, 2026

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