Endothelial cell, but not neutrophil, programmed cell death receptor-ligand 1 loss has a morbid impact on experimental murine shock/sepsis-induced lung injury - Scorecard - MDSpire

Endothelial cell, but not neutrophil, programmed cell death receptor-ligand 1 loss has a morbid impact on experimental murine shock/sepsis-induced lung injury

  • By

  • Elizabeth W. Tindal

  • Chun-Shiang Chung

  • Yaping Chen

  • Runping Zhao

  • Fernando Gutierrez Garcia

  • Theopi Rados

  • Sean F. Monaghan

  • Alfred Ayala

  • June 2, 2026

  • 0 min

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Clinical Scorecard: Loss of Programmed Cell Death Receptor-Ligand 1 in Endothelial Cells, but Not Neutrophils, Significantly Affects Lung Injury in Experimental Murine Models of Shock and Sepsis

At a Glance

CategoryDetail
Condition
Key Mechanisms
Target PopulationAdult male C57BL/6 mice; findings may not be directly applicable to human populations.
Care Setting

Key Highlights

  • Specify which cytokines showed significant variation between ecPD-L1−/− and pmnPD-L1−/− mice.

Guideline-Based Recommendations

Diagnosis

    Management

    • Consider specific PD-L1 targeting strategies, such as monoclonal antibodies or small molecules.

    Monitoring & Follow-up

      Risks

        Patient & Prescribing Data

        Highlight the gap in translating murine findings to human clinical settings; emphasize the need for further research.

        Clinical Best Practices

        • Develop specific protocols for assessing PD-L1 roles in clinical settings based on experimental findings.

        Related Resources & Content

        Original Source(s)

        Endothelial cell, but not neutrophil, programmed cell death receptor-ligand 1 loss has a morbid impact on experimental murine shock/sepsis-induced lung injury

        • by Elizabeth W. Tindal, Chun-Shiang Chung, Yaping Chen, Runping Zhao, Fernando Gutierrez Garcia, Theopi Rados, Sean F. Monaghan, Alfred Ayala

        • June 2, 2026

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