Case Report: Clinicopathological features and outcomes of superficial cervicovaginal myofibroblastoma: analysis of two cases and a review of the literature
By
Xiaoli Cai
Yanli Liu
Yunfeng Niu
Xiaodan Shen
Qian Zhang
Lei Liang
Shuang Liu
May 13, 2026
Clinical Scorecard: Clinical Insights and Outcomes of Superficial Cervicovaginal Myofibroblastoma: A Report on Two Cases and Literature Review
At a Glance
Category Detail
Condition Superficial cervicovaginal myofibroblastoma (SCVM)
Key Mechanisms Benign mesenchymal tumor arising from the superficial stromal layer of the submucosal vagina and cervix.
Target Population Women aged 20–60 years.
Care Setting Gynecological clinics and surgical settings.
Key Highlights
SCVM is clinically rare, representing less than 0.1% of benign tumors. Common symptoms include irregular vaginal bleeding and incidental findings. Surgical excision is the primary treatment with a favorable prognosis and low recurrence rate. Accurate diagnosis requires histopathological and immunohistochemical evaluation. The tumor demonstrates hormone-related characteristics and slow growth.
Guideline-Based Recommendations
Diagnosis
Utilize integrated evaluation of histopathological morphology and immunohistochemical profiles.
Management
Surgical resection is recommended as the primary treatment approach.
Monitoring & Follow-up
Follow-up periods should be conducted to monitor for recurrence, typically ranging from 6 months to 1 year.
Risks
Misdiagnosis or overtreatment due to overlapping features with other soft tissue tumors.
Patient & Prescribing Data
Female patients aged 20–60 years with SCVM.
Surgical excision is effective with no reported recurrence in follow-up.
Clinical Best Practices
Conduct thorough gynecological examinations to identify incidental findings. Employ imaging techniques like gynecological ultrasonography for initial assessment. Ensure comprehensive pathological analysis to differentiate SCVM from other tumors.
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