Clinical Case Study: Diffuse Subretinal Fibrosis and Uveitis Syndrome Accompanied by Vitreoretinal Traction Syndrome
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By
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Xiaohua Zhang
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Yongping Hu
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Jian Li
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May 7, 2026
Clinical Scorecard: Clinical Case Study: Diffuse Subretinal Fibrosis and Uveitis Syndrome Accompanied by Vitreoretinal Traction Syndrome
At a Glance
| Category | Detail |
|---|
| Condition | Diffuse Subretinal Fibrosis and Uveitis (SFU) Syndrome |
| Key Mechanisms | Autoimmune-mediated mechanism targeting the retinal pigment epithelium and inner choroid. |
| Target Population | Adults, typically healthy, with a rare incidence of SFU syndrome. |
| Care Setting | Ophthalmology clinic and surgical intervention. |
Key Highlights
- 67-year-old female with bilateral SFU syndrome and VRT syndrome.
- 4-year gap between onset of symptoms in each eye.
- Diagnosis confirmed through fundus fluorescein angiography.
- Treatment included pars plana vitrectomy and intraocular triamcinolone.
- Anti-VEGF therapy provided partial response for macular edema.
Guideline-Based Recommendations
Diagnosis
- Clinical assessment and imaging (FFA) to confirm SFU and VRT.
Management
- Surgical intervention for significant vitreoretinal traction.
- Systemic glucocorticoids and immunosuppressive therapy.
Monitoring & Follow-up
- Regular follow-up for recurrence of macular edema and visual acuity.
Risks
- Potential for irreversible vision loss due to subretinal fibrosis.
Patient & Prescribing Data
Older adults with SFU syndrome and associated complications.
Combination of surgical and pharmacological approaches may be necessary.
Clinical Best Practices
- Early intervention in cases of significant vitreoretinal traction.
- Consideration of biologic therapies in refractory cases.
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