Case Report: A case of diffuse subretinal fibrosis and uveitis syndrome with vitreoretinal traction syndrome - Scorecard - MDSpire

Case Report: A case of diffuse subretinal fibrosis and uveitis syndrome with vitreoretinal traction syndrome

  • By

  • Xiaohua Zhang

  • Yongping Hu

  • Jian Li

  • May 7, 2026

  • 0 min

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Clinical Scorecard: Clinical Case Study: Diffuse Subretinal Fibrosis and Uveitis Syndrome Accompanied by Vitreoretinal Traction Syndrome

At a Glance

CategoryDetail
ConditionDiffuse Subretinal Fibrosis and Uveitis (SFU) Syndrome
Key MechanismsAutoimmune-mediated mechanism targeting the retinal pigment epithelium and inner choroid.
Target PopulationAdults, typically healthy, with a rare incidence of SFU syndrome.
Care SettingOphthalmology clinic and surgical intervention.

Key Highlights

  • 67-year-old female with bilateral SFU syndrome and VRT syndrome.
  • 4-year gap between onset of symptoms in each eye.
  • Diagnosis confirmed through fundus fluorescein angiography.
  • Treatment included pars plana vitrectomy and intraocular triamcinolone.
  • Anti-VEGF therapy provided partial response for macular edema.

Guideline-Based Recommendations

Diagnosis

  • Clinical assessment and imaging (FFA) to confirm SFU and VRT.

Management

  • Surgical intervention for significant vitreoretinal traction.
  • Systemic glucocorticoids and immunosuppressive therapy.

Monitoring & Follow-up

  • Regular follow-up for recurrence of macular edema and visual acuity.

Risks

  • Potential for irreversible vision loss due to subretinal fibrosis.

Patient & Prescribing Data

Older adults with SFU syndrome and associated complications.

Combination of surgical and pharmacological approaches may be necessary.

Clinical Best Practices

  • Early intervention in cases of significant vitreoretinal traction.
  • Consideration of biologic therapies in refractory cases.

Related Resources & Content

Original Source(s)

Case Report: A case of diffuse subretinal fibrosis and uveitis syndrome with vitreoretinal traction syndrome

  • by Xiaohua Zhang, Yongping Hu, Jian Li

  • May 7, 2026

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