Genomic epidemiology of the 2025 mpox epidemic in Sierra Leone - Scorecard - MDSpire

Genomic epidemiology of the 2025 mpox epidemic in Sierra Leone

  • By

  • Allan K. O. Campbell

  • John Demby Sandi

  • Ifeanyi F. Omah

  • Martin Faye

  • Edyth Parker

  • Taylor Brock-Fisher

  • Crystal M. Gigante

  • Vidalyn Folorunso

  • Mohamed Saio Kamara

  • Anu Jegede Williams

  • Mouhamed Kane

  • Tiangay Mariama Patience Sallay Kallon

  • Julian Campbell

  • Kadiatu Salmata Sesay

  • Sia Mani

  • Choe Miller

  • Naomi Daniel Sesay

  • Francis Baimba

  • Mignane Ndiaye

  • Roberta Lansana

  • Ibrahim Umaru Fofanah

  • Simon Ruhweza

  • Zein Souma

  • Amanda Kargbo

  • Komba Koninga

  • Alie Tia

  • Jone Ngobeh

  • Foday Thoronka

  • Alusine Fofanah

  • Al Ozonoff

  • Colby Wilkason

  • Danny Park

  • Christopher Tomkins-Tinch

  • Marietou F. Paye

  • Christopher Shin

  • Ian Baudi

  • Brendan Blumenstiel

  • Patrick Varilly

  • Ivan Specht

  • Ben Fry

  • Karlie Zhao

  • Paul Cronan

  • Ellory Laning

  • Oludayo Oluwaseyi Ope-ewe

  • Ayotunde Elijah Sijuwola

  • Femi Saibu

  • Harouna Soumare

  • Ebenezer Kehinde Ogundana

  • Ruth Oluwaseun Obaado

  • Jolly Amoche Adole

  • Imonikhe Kennedy Kio

  • Folefac Agnes Njeandoh

  • Alexandra Tuttle

  • Walter O. Oguta

  • Jonathan Greene

  • Aminata Koroma

  • Joseph Kanu

  • Mamadou Aliou Barry

  • Aboubacry Gaye

  • Andy Mahine Diouf

  • Christine Hughes

  • Joshua I. Levy

  • Alhaji N’jai

  • Moussa Moise Diagne

  • Dolo Nosamiefan

  • George Ameh

  • John Klena

  • Monique A. Foster

  • Abebaw Kebede

  • Collins Tanui

  • Boubacar Diallo

  • Anise Happi

  • Sofonias Tessema

  • Abdourahmane Sow

  • Yenew Kebede

  • Isatta Wurie

  • James Squire

  • Doris Harding

  • Zikan Koroma

  • Mohamed Boie Jalloh

  • Amadou Alpha Sall

  • Kristian G. Andersen

  • Andrew Rambaut

  • Mohamed Alex Vandi

  • Ibrahima Socé Fall

  • Pardis Sabeti

  • Christian Happi

  • Foday Sahr

  • Donald S. Grant

  • May 12, 2026

  • 0 min

Share

Clinical Scorecard: Genomic Analysis of the Mpox Outbreak in Sierra Leone, 2025

At a Glance

CategoryDetail
Condition
Key Mechanisms
Target PopulationYoung adults aged 16–35 years, with a near-equal sex distribution, reflecting outbreak demographics.
Care Setting

Key Highlights

  • Clarify the outbreak's link to clade IIb/sh2017 lineage A viruses based on genomic analysis.

Guideline-Based Recommendations

Diagnosis

    Management

      Monitoring & Follow-up

      • Conduct ongoing genomic surveillance to track transmission dynamics and monitor for co-infections and contextual factors affecting clinical severity.

      Risks

        Patient & Prescribing Data

        Outcomes vary significantly based on the quality of supportive care, emphasizing the need for high-quality supportive care.

        Clinical Best Practices

        • Implement rapid testing and case isolation to control outbreaks.
        • Engage in contact tracing within high-mobility networks.
        • Educate communities about transmission risks and prevention strategies, focusing on high-risk groups.

        Related Resources & Content

        Original Source(s)

        Genomic epidemiology of the 2025 mpox epidemic in Sierra Leone

        • by Allan K. O. Campbell, John Demby Sandi, Ifeanyi F. Omah, Martin Faye, Edyth Parker, Taylor Brock-Fisher, Crystal M. Gigante, Vidalyn Folorunso, Mohamed Saio Kamara, Anu Jegede Williams, Mouhamed Kane, Tiangay Mariama Patience Sallay Kallon, Julian Campbell, Kadiatu Salmata Sesay, Sia Mani, Choe Miller, Naomi Daniel Sesay, Francis Baimba, Mignane Ndiaye, Roberta Lansana, Ibrahim Umaru Fofanah, Simon Ruhweza, Zein Souma, Amanda Kargbo, Komba Koninga, Alie Tia, Jone Ngobeh, Foday Thoronka, Alusine Fofanah, Al Ozonoff, Colby Wilkason, Danny Park, Christopher Tomkins-Tinch, Marietou F. Paye, Christopher Shin, Ian Baudi, Brendan Blumenstiel, Patrick Varilly, Ivan Specht, Ben Fry, Karlie Zhao, Paul Cronan, Ellory Laning, Oludayo Oluwaseyi Ope-ewe, Ayotunde Elijah Sijuwola, Femi Saibu, Harouna Soumare, Ebenezer Kehinde Ogundana, Ruth Oluwaseun Obaado, Jolly Amoche Adole, Imonikhe Kennedy Kio, Folefac Agnes Njeandoh, Alexandra Tuttle, Walter O. Oguta, Jonathan Greene, Aminata Koroma, Joseph Kanu, Mamadou Aliou Barry, Aboubacry Gaye, Andy Mahine Diouf, Christine Hughes, Joshua I. Levy, Alhaji N’jai, Moussa Moise Diagne, Dolo Nosamiefan, George Ameh, John Klena, Monique A. Foster, Abebaw Kebede, Collins Tanui, Boubacar Diallo, Anise Happi, Sofonias Tessema, Abdourahmane Sow, Yenew Kebede, Isatta Wurie, James Squire, Doris Harding, Zikan Koroma, Mohamed Boie Jalloh, Amadou Alpha Sall, Kristian G. Andersen, Andrew Rambaut, Mohamed Alex Vandi, Ibrahima Socé Fall, Pardis Sabeti, Christian Happi, Foday Sahr, Donald S. Grant

        • May 12, 2026

        Related Content

        HHS Supports Repatriation of U.S. Citizens to Specialized Care Facilities

        FDA Monthly Preview: Key June Decisions to Watch

        Several FDA decisions across multiple specialties are expected this month.

        FDA Expands ASCENIV Pediatric Use

        Label change follows completion of required pediatric evaluation and updates prior age restrictions for treatment eligibility.