Effect of bariatric surgery on matrix metalloproteinase activity in patients with morbid obesity - Scorecard - MDSpire

Effect of bariatric surgery on matrix metalloproteinase activity in patients with morbid obesity

  • By

  • Barbara Choromańska

  • Piotr Myśliwiec

  • Jacek Dadan

  • Alan Tkaczuk

  • Konrad Wiśniewski

  • Almantas Maleckas

  • Anna Zalewska

  • Małgorzata Żendzian-Piotrowska

  • Mateusz Maciejczyk

  • June 15, 2026

  • 0 min

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Clinical Scorecard: Impact of Laparoscopic Sleeve Gastrectomy on Matrix Metalloproteinase Activity in Individuals with Severe Obesity

At a Glance

CategoryDetail
Condition
Key MechanismsMatrix metalloproteinases (MMPs) involved in extracellular matrix remodeling and metabolic complications.
Target Population
Care Setting

Key Highlights

  • Increased plasma activities of MMPs observed in morbidly obese women.
  • Bariatric surgery partially normalizes MMP activity but disturbances persist.
  • Differences in MMP activity noted between obese individuals with and without metabolic syndrome.

Guideline-Based Recommendations

Diagnosis

  • Classify obesity using BMI > 40 kg/m2.
  • Assess metabolic syndrome according to International Diabetes Federation guidelines.

Management

  • Consider laparoscopic sleeve gastrectomy for severe obesity.

Monitoring & Follow-up

  • Evaluate plasma MMP activity pre- and post-bariatric surgery.

Risks

  • Increased MMP activity associated with obesity-related metabolic complications.

Patient & Prescribing Data

63 women with class 3 obesity undergoing bariatric surgery.

Clinical Best Practices

    Related Resources & Content

    Original Source(s)

    Effect of bariatric surgery on matrix metalloproteinase activity in patients with morbid obesity

    • by Barbara Choromańska, Piotr Myśliwiec, Jacek Dadan, Alan Tkaczuk, Konrad Wiśniewski, Almantas Maleckas, Anna Zalewska, Małgorzata Żendzian-Piotrowska, Mateusz Maciejczyk

    • June 15, 2026

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