Dietary fibers to boost endogenous GLP-1 secretion and satiety: a scoping review
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By
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Jelle C. B. C. de Jong
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Milou G. W. Lentjes
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Karleen F. Pietersma
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Wilrike J. Pasman
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Suzan Wopereis
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Femke P. M. Hoevenaars
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July 15, 2026
Clinical Scorecard: Enhancing Endogenous GLP-1 Secretion and Satiety Through Dietary Fibers: A Scoping Review
At a Glance
| Category | Detail |
|---|
| Condition | Dietary Fiber and GLP-1 Secretion |
| Key Mechanisms | Microbial fermentation and gut hormone signaling enhance GLP-1 secretion and satiety. |
| Target Population | Adults with overweight, obesity, type 2 diabetes mellitus, metabolic syndrome, and healthy adults. |
| Care Setting | Clinical trials assessing dietary interventions. |
Key Highlights
- Dextrins show robust effects on both GLP-1 secretion and satiety.
- Most studies were acute interventions conducted in Western populations.
- Evidence remains constrained by small sample sizes and short interventions.
- Longer-term studies are needed to capture microbiota adaptation.
- Dietary strategies can support tapering of GLP-1 receptor agonist therapy.
Guideline-Based Recommendations
Diagnosis
- Assess GLP-1 levels and satiety in individuals undergoing weight management.
Management
- Incorporate dietary fibers, particularly dextrins, to enhance GLP-1 secretion.
Monitoring & Follow-up
- Evaluate changes in satiety and weight management outcomes during dietary fiber supplementation.
Risks
- Consider potential gastrointestinal side effects from increased dietary fiber intake.
Patient & Prescribing Data
Adults with obesity, type 2 diabetes, or metabolic syndrome.
Dietary fibers can be a low-risk adjunct to pharmacotherapy for weight management.
Clinical Best Practices
- Utilize a variety of dietary fibers to assess individual responses.
- Monitor patient adherence and tolerance to dietary fiber interventions.
- Encourage integration of dietary strategies into routine obesity care.
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