Analysis of mortality risk and influencing factors in female patients with young-onset type 2 diabetes
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By
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Ling Xiang
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Mingmin Zhu
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Zi Yan
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Zhijin Geng
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Yuankai Zhou
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Zhongming Sun
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Dandan Miao
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Yong Zhang
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Jinyi Zhou
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Enchun Pan
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Wen Hu
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April 17, 2026
Clinical Scorecard: Evaluation of mortality risk and contributing factors among women with early-onset type 2 diabetes mellitus
At a Glance
| Category | Detail |
|---|
| Condition | Early-onset type 2 diabetes mellitus (YOD) |
| Key Mechanisms | Influence of triglyceride–glucose–body mass index (TyG-BMI) on mortality risk |
| Target Population | Female patients diagnosed with type 2 diabetes mellitus under 40 years |
| Care Setting | Community-based health services in Jiangsu Province, China |
Key Highlights
- All-cause mortality rate for YOD patients is lower than for late-onset patients.
- Postmenopausal women with YOD have higher mortality rates compared to premenopausal women.
- TyG-BMI is an independent protective factor for mortality in the young menopausal group.
Guideline-Based Recommendations
Diagnosis
- Early identification of type 2 diabetes in women under 40 years.
Management
- Monitor and manage TyG-BMI levels in postmenopausal women with YOD.
Monitoring & Follow-up
- Regular follow-up for all-cause mortality risk in young women with diabetes.
Risks
- Increased mortality risk associated with higher triglyceride levels and lower BMI.
Patient & Prescribing Data
Female patients with early-onset type 2 diabetes mellitus
Interventions targeting TyG-BMI may reduce mortality risk.
Clinical Best Practices
- Implement community-based screening for early-onset type 2 diabetes.
- Educate patients on the importance of managing triglyceride levels.
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