From algorithm to verification: based on network toxicology and machine learning, the immunomodulatory role of IGFBP1/MKI67/C9 in perfluorooctanoic acid-induced osteoarthritis was discovered, and a diagnostic model was constructed - Scorecard - MDSpire
Coming Soon: Introducing MDSpire News. Learn more
Conexiant’s news site is now MDSpire News. Learn more

Unveiling the Immunomodulatory Effects of IGFBP1/MKI67/C9 in Perfluorooctanoic Acid-Induced Osteoarthritis: A Machine Learning and Network Toxicology Approach to Model Verification

  • By

  • Xinzhou Huang

  • Yongkun Wei

  • Yani Rao

  • Yue Wei

  • Hui Chen

  • Yunping Bao

  • May 28, 2026

Share

Clinical Scorecard: Unveiling the Immunomodulatory Effects of IGFBP1/MKI67/C9 in Perfluorooctanoic Acid-Induced Osteoarthritis: A Machine Learning and Network Toxicology Approach to Model Verification

At a Glance

CategoryDetail
Condition
Key MechanismsRevise to ensure claims are directly sourced.
Target Population
Care Setting

Key Highlights

  • nomogram

Guideline-Based Recommendations

Diagnosis

  • E
  • n
  • s
  • u
  • r
  • e
  • r
  • e
  • c
  • o
  • m
  • m
  • e
  • n
  • d
  • a
  • t
  • i
  • o
  • n
  • s
  • a
  • r
  • e
  • s
  • o
  • u
  • r
  • c
  • e
  • d
  • f
  • r
  • o
  • m
  • g
  • u
  • i
  • d
  • e
  • l
  • i
  • n
  • e
  • s
  • o
  • r
  • s
  • t
  • u
  • d
  • i
  • e
  • s
  • .

Management

  • E
  • n
  • s
  • u
  • r
  • e
  • r
  • e
  • c
  • o
  • m
  • m
  • e
  • n
  • d
  • a
  • t
  • i
  • o
  • n
  • s
  • a
  • r
  • e
  • s
  • o
  • u
  • r
  • c
  • e
  • d
  • f
  • r
  • o
  • m
  • g
  • u
  • i
  • d
  • e
  • l
  • i
  • n
  • e
  • s
  • o
  • r
  • s
  • t
  • u
  • d
  • i
  • e
  • s
  • .

Monitoring & Follow-up

  • E
  • n
  • s
  • u
  • r
  • e
  • r
  • e
  • c
  • o
  • m
  • m
  • e
  • n
  • d
  • a
  • t
  • i
  • o
  • n
  • s
  • a
  • r
  • e
  • s
  • o
  • u
  • r
  • c
  • e
  • d
  • f
  • r
  • o
  • m
  • g
  • u
  • i
  • d
  • e
  • l
  • i
  • n
  • e
  • s
  • o
  • r
  • s
  • t
  • u
  • d
  • i
  • e
  • s
  • .

Risks

  • E
  • n
  • s
  • u
  • r
  • e
  • c
  • l
  • a
  • i
  • m
  • s
  • a
  • r
  • e
  • d
  • i
  • r
  • e
  • c
  • t
  • l
  • y
  • s
  • o
  • u
  • r
  • c
  • e
  • d
  • .

Patient & Prescribing Data

Support insights with specific studies or guidelines.

Clinical Best Practices

  • best_practices

Related Resources & Content

Original Source(s)

From algorithm to verification: based on network toxicology and machine learning, the immunomodulatory role of IGFBP1/MKI67/C9 in perfluorooctanoic acid-induced osteoarthritis was discovered, and a diagnostic model was constructed

  • by Xinzhou Huang, Yongkun Wei, Yani Rao, Yue Wei, Hui Chen, Yunping Bao

  • May 28, 2026

Related Content

PT vs CBT for Chronic Low Back Pain

Sequential, multiple-assignment randomized trial compares stage I and stage II nonpharmacologic treatments over 52 weeks.

Development and validation of a uric acid-inflammation-metabolism score for predicting osteoarthritis risk: evidence from NHANES 2007–2018 and an external Chinese cohort

SEMA4A signaling in macrophage subpopulations and its implication in osteoarthritis