Early osseointegration of two in-house 3D-printed porous titanium implant designs: an in vivo sheep study
By
Anna B. Borgognoni
Sarah S. Freund
Jørgen Baas
Michael M. Bendtsen
Jeppe S. Byskov
Bahram Ranjkesh
Jens R. Nyengaard
Ruben Pauwels
Thomas Baad-Hansen
May 25, 2026
Clinical Scorecard: In Vivo Evaluation of Early Osseointegration in Two Custom 3D-Printed Porous Titanium Implant Designs in Sheep
At a Glance
Category Detail
Condition Early osseointegration of titanium implants Key Mechanisms Promotes cellular migration and tissue formation through porous surfaces Target Population Skeletally mature sheep Care Setting Animal research facility
Key Highlights
Comparison of two custom 3D-printed titanium implants with different pore sizes and porosities No significant differences in mechanical strength, energy, or stiffness between implant designs Histomorphometric analysis showed no significant differences in bone or fibrous tissue fractions Study conducted on 20 female Romney-Texel sheep Implants designed to optimize both biological and mechanical properties Guideline-Based Recommendations
Diagnosis
Management
Monitoring & Follow-up
Risks
Patient & Prescribing Data
Not applicable (animal study)
Implant designs aimed to enhance early osseointegration without compromising mechanical integrity
Clinical Best Practices
Prioritize factors that promote optimal bone fixation in implant design Balance porosity with mechanical strength in implant fabrication Utilize 3D printing for precise control over implant characteristics Related Resources & Content
