A multi-mineral intervention is associated with improved intestinal permeability in patients with ulcerative colitis: results from a pilot trial - Scorecard - MDSpire
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A multi-mineral intervention is associated with improved intestinal permeability in patients with ulcerative colitis: results from a pilot trial
Clinical Scorecard: A pilot study indicates that a multi-mineral supplement may enhance intestinal barrier function in individuals with ulcerative colitis.
At a Glance
Category
Detail
Condition
Ulcerative Colitis
Key Mechanisms
Enhancement of gut barrier protein expression and reduction in intestinal permeability.
Target Population
Individuals with mild ulcerative colitis or UC in remission.
Care Setting
Clinical trial setting.
Key Highlights
Aquamin® supplementation reduced urinary mannitol excretion in UC patients.
Statistically significant reduction in mannitol levels at multiple time points post-supplementation.
Aquamin® was well tolerated with no serious adverse events reported.
Baseline urinary mannitol levels were significantly higher in UC patients compared to healthy controls.
Modest reduction in alkaline phosphatase levels observed after 90 days of intervention.
Guideline-Based Recommendations
Diagnosis
Assessment of intestinal permeability is used for disease monitoring in UC.
Management
Aquamin® may serve as an adjunct to current UC management strategies.
Monitoring & Follow-up
Monitor urinary mannitol excretion as a measure of intestinal permeability.
Risks
No serious adverse events reported; further studies needed to confirm safety and efficacy.
Patient & Prescribing Data
Patients with mild ulcerative colitis or UC in remission.
Aquamin® supplementation may improve gut barrier function.
Clinical Best Practices
Consider Aquamin® as a potential adjunct therapy for UC management.
Evaluate intestinal permeability as part of routine monitoring in UC patients.
