Assessment of hemoglobin-to-red cell distribution width ratio to predict all-cause mortality in patients with sepsis: a retrospective cohort study from the MIMIC-IV database - Scorecard - MDSpire

Assessment of hemoglobin-to-red cell distribution width ratio to predict all-cause mortality in patients with sepsis: a retrospective cohort study from the MIMIC-IV database

  • By

  • Zhiwei Su

  • Yin Wen

  • Wenhong Zhong

  • Hongguang Ding

  • Hongke Zeng

  • July 13, 2026

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Clinical Scorecard: Evaluation of the Hemoglobin-to-Red Cell Distribution Width Ratio as a Predictor of All-Cause Mortality in Sepsis Patients: Insights from a Retrospective Analysis of the MIMIC-IV Database

At a Glance

CategoryDetail
ConditionSepsis
Key MechanismsHemoglobin-to-Red Cell Distribution Width Ratio (HRR) as a prognostic indicator.
Target PopulationAdult critically ill patients with sepsis.
Care SettingICU

Key Highlights

  • 28,812 sepsis patients analyzed; 5,697 (19.77%) died within 28 days.
  • High HRR group had a lower 28-day mortality rate (20.23%) compared to low HRR group (25.72%).
  • HRR below 0.78 correlates with a 26% decrease in mortality risk per unit increase.

Guideline-Based Recommendations

Diagnosis

  • Use HRR as a potential prognostic marker in sepsis patients.

Management

  • Integrate HRR into existing scoring models to enhance predictive accuracy.

Monitoring & Follow-up

  • Monitor HRR alongside disease severity scores for better prognosis assessment.

Risks

  • Lower HRR is associated with higher mortality risk in sepsis patients.

Patient & Prescribing Data

Adult patients with sepsis in ICU settings.

HRR may serve as a non-invasive biomarker for assessing prognosis.

Clinical Best Practices

  • Utilize HRR in conjunction with other established biomarkers for comprehensive patient assessment.
  • Conduct regular assessments of HRR to inform clinical decisions in sepsis management.

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