α-cell SLC38A5 supports amino acid-induced α-cell proliferation and glucagon secretion - Scorecard - MDSpire

α-cell SLC38A5 supports amino acid-induced α-cell proliferation and glucagon secretion

  • By

  • Katelyn Sellick

  • Anna Marie R. Schornack

  • Tyler J. Rodgers

  • Fedora O. Ogodo

  • Mounika Aramandla

  • Jade E. Stanley

  • Walter Siv

  • Matthew Shou

  • Nitin C. Shankar

  • Soham S. Saraf

  • Diana E. Stanescu

  • E. Danielle Dean

  • June 15, 2026

  • 0 min

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Clinical Scorecard: The Role of SLC38A5 in Promoting α-Cell Growth and Glucagon Release in Response to Amino Acids

At a Glance

CategoryDetail
Condition
Key Mechanisms
Target PopulationIndividuals with diabetes experiencing glucagon dysregulation.
Care Setting

Key Highlights

  • SLC38A5 is essential for amino acid-induced glucagon secretion and α-cell proliferation.
  • α-cell-specific deletion of Slc38a5 reduces glucagon secretion despite elevated amino acids.
  • SLC38A5 is highly expressed in pancreatic α cells in both mice and humans.

Guideline-Based Recommendations

Diagnosis

  • Monitor glucagon levels in patients with diabetes.

Management

  • Consider targeting amino acid transport mechanisms.

Monitoring & Follow-up

  • Evaluate circulating amino acid levels.

Risks

  • Dysregulated glucagon secretion can lead to hyperglycemia.

Patient & Prescribing Data

Understanding SLC38A5's role may inform future treatments.

Clinical Best Practices

  • Assess the role of amino acids in glucagon secretion.
  • Investigate the impact of SLC38A5 on α-cell biology.

Related Resources & Content

Original Source(s)

α-cell SLC38A5 supports amino acid-induced α-cell proliferation and glucagon secretion

  • by Katelyn Sellick, Anna Marie R. Schornack, Tyler J. Rodgers, Fedora O. Ogodo, Mounika Aramandla, Jade E. Stanley, Walter Siv, Matthew Shou, Nitin C. Shankar, Soham S. Saraf, Diana E. Stanescu, E. Danielle Dean

  • June 15, 2026

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