Melatonin-induced restoration of the intestinal mucosal barrier in inflammatory bowel disease via activation of the SIRT1-LKB1-pAMPK axis - Scorecard - MDSpire
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Melatonin-induced restoration of the intestinal mucosal barrier in inflammatory bowel disease via activation of the SIRT1-LKB1-pAMPK axis
Clinical Scorecard: Restoration of the Intestinal Mucosal Barrier in Inflammatory Bowel Disease through Melatonin and the Activation of the SIRT1-LKB1-pAMPK Pathway
At a Glance
Category
Detail
Condition
Key Mechanisms
Target Population
Patients with Inflammatory Bowel Disease, including Crohn’s disease and ulcerative colitis, across various age groups.
Care Setting
Key Highlights
Melatonin enhances intestinal antimicrobial peptides and alleviates colitis through modulation of gut microbiota.
Guideline-Based Recommendations
Diagnosis
Management
Consider melatonin supplementation (e.g., 3-5 mg at bedtime) for IBD patients to improve gut health.
Monitoring & Follow-up
Risks
Patient & Prescribing Data
Patients with IBD, including those with Crohn’s disease and ulcerative colitis.
Melatonin may improve intestinal barrier integrity and reduce inflammation.
Clinical Best Practices
Incorporate assessment of sleep quality in IBD management, supported by recent studies.
