Discriminating prevalent type 2 diabetes among community-dwelling older adults with metabolic dysfunction-associated steatotic liver disease: a comparative analysis of 12 insulin resistance surrogates - Scorecard - MDSpire

Discriminating prevalent type 2 diabetes among community-dwelling older adults with metabolic dysfunction-associated steatotic liver disease: a comparative analysis of 12 insulin resistance surrogates

  • By

  • Xianshang Zhu

  • Zengrui Wang

  • Yan Fang

  • Zong Ning

  • Xia Yang

  • July 8, 2026

  • 0 min

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Clinical Scorecard: Identifying Prevalent Type 2 Diabetes in Older Adults with Metabolic Dysfunction-Associated Fatty Liver Disease: A Comparative Study of 12 Insulin Resistance Indices

At a Glance

CategoryDetail
ConditionType 2 Diabetes Mellitus (T2DM)
Key MechanismsInsulin resistance (IR) promotes hepatic lipid accumulation and impairs glucose utilization.
Target PopulationOlder adults with metabolic dysfunction-associated fatty liver disease (MASLD).
Care SettingCommunity health examination.

Key Highlights

  • TyG, TyG-ABSI, TyG-WWI, and TyG-WC are associated with prevalent T2DM.
  • TyG index showed the highest discriminatory ability (AUC = 0.726).
  • The pooled prevalence of T2DM in patients with MASLD is 19.7%.
  • The prevalence of diabetes among patients with MASLD ranges from 25.0% to 33.9%.
  • Early identification of T2DM in this population is clinically important.

Guideline-Based Recommendations

Diagnosis

  • Use surrogate insulin resistance indices for identifying T2DM in older adults with MASLD.

Management

    Monitoring & Follow-up

      Risks

      • Coexistence of T2DM in patients with MASLD increases risks of cardiovascular disease, chronic kidney disease, and all-cause mortality.

      Patient & Prescribing Data

      Older adults with metabolic dysfunction-associated fatty liver disease.

      Simple and reproducible surrogate markers of insulin resistance are valuable for early detection of T2DM.

      Clinical Best Practices

      • Implement routine screening for T2DM using accessible insulin resistance indices in community settings.

      Related Resources & Content

      Original Source(s)

      Discriminating prevalent type 2 diabetes among community-dwelling older adults with metabolic dysfunction-associated steatotic liver disease: a comparative analysis of 12 insulin resistance surrogates

      • by Xianshang Zhu, Zengrui Wang, Yan Fang, Zong Ning, Xia Yang

      • July 8, 2026

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