Tao-Hong-Si-Wu-Tang protects against methionine- and choline-deficient diet-induced hepatic steatosis in rats and is associated with inhibition of oxidative stress, inflammation, apoptosis, and pyroptosis - Scorecard - MDSpire

Tao-Hong-Si-Wu-Tang protects against methionine- and choline-deficient diet-induced hepatic steatosis in rats and is associated with inhibition of oxidative stress, inflammation, apoptosis, and pyroptosis

  • By

  • Luyao Xu

  • Qiuling Li

  • Chengqin Lu

  • Mincheng Zheng

  • Wenhai Guo

  • Yun Chen

  • Jiaying Dai

  • Yao Deng

  • Ning Zhang

  • Kanlin Yang

  • Xinling Chen

  • Kangrong Wang

  • Guohang Yan

  • Hantao Li

  • Rui Duan

  • Jiean Xu

  • Wei Liu

  • Hongzhi Yang

  • Jinwen Xu

  • Min Dai

  • Yaxing Zhang

  • July 6, 2026

  • 0 min

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Clinical Scorecard: Tao-Hong-Si-Wu-Tang Mitigates Hepatic Steatosis Induced by Methionine and Choline Deficiency in Rats, Linked to Reduced Oxidative Stress, Inflammation, Apoptosis, and Pyroptosis

At a Glance

CategoryDetail
ConditionNon-alcoholic fatty liver disease (NAFLD)
Key MechanismsOxidative stress reduction, inflammation inhibition, apoptosis and pyroptosis suppression
Target PopulationAdult population with NAFLD
Care SettingResearch setting using animal models

Key Highlights

  • THSWT treatment (2.5 g/kg/day) alleviates hepatic steatosis in rats
  • Mechanisms include reduction of hepatic reactive oxygen species and pro-inflammatory cytokines
  • THSWT shows potential for hepatoprotection in NAFLD treatment

Guideline-Based Recommendations

Diagnosis

  • NAFLD is diagnosed by fat accumulation in hepatocytes without secondary causes

Management

  • Current treatments include lifestyle interventions and management of metabolic comorbidities

Monitoring & Follow-up

  • Evaluate hepatic steatosis through histological staining and serum liver enzyme levels

Risks

  • NAFLD can progress to NASH, hepatic fibrosis, cirrhosis, and hepatocellular carcinoma

Patient & Prescribing Data

Rats used in the study to model NAFLD

THSWT may serve as a candidate drug for NAFLD treatment

Clinical Best Practices

  • Consider traditional Chinese medicine formulas like THSWT for hepatoprotection
  • Monitor oxidative stress and inflammatory markers in NAFLD patients

Related Resources & Content

Original Source(s)

Tao-Hong-Si-Wu-Tang protects against methionine- and choline-deficient diet-induced hepatic steatosis in rats and is associated with inhibition of oxidative stress, inflammation, apoptosis, and pyroptosis

  • by Luyao Xu, Qiuling Li, Chengqin Lu, Mincheng Zheng, Wenhai Guo, Yun Chen, Jiaying Dai, Yao Deng, Ning Zhang, Kanlin Yang, Xinling Chen, Kangrong Wang, Guohang Yan, Hantao Li, Rui Duan, Jiean Xu, Wei Liu, Hongzhi Yang, Jinwen Xu, Min Dai, Yaxing Zhang

  • July 6, 2026

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