Gestational diabetes mellitus–induced adipokine dysregulation and links to metabolic programming risks
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By
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Jolanta Lis‐Kuberka
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Marta Berghausen‐Mazur
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May 12, 2026
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Clinical Scorecard: Adipokine Imbalance Induced by Gestational Diabetes Mellitus and Its Association with Metabolic Programming Risks
At a Glance
| Category | Detail |
|---|
| Condition | |
| Key Mechanisms | Disruption of maternal-fetal glucose homeostasis, inflammation, insulin resistance, and metabolic dysregulation. |
| Target Population | |
| Care Setting | |
Key Highlights
- GDM is associated with increased maternal leptin and altered adipokine profiles, contributing to metabolic dysregulation.
- Higher maternal leptin and LAR indicate insulin resistance and metabolic stress, increasing long-term risks.
Guideline-Based Recommendations
Diagnosis
Management
- Monitor maternal glucose levels and manage with diet or insulin as needed, including specific dietary guidelines.
Monitoring & Follow-up
Risks
Patient & Prescribing Data
Pregnant women with GDM.
Dietary management and insulin therapy may be required based on severity.
Clinical Best Practices
- Implement lifestyle interventions such as physical activity and nutritional counseling to manage weight and improve metabolic health.
References
