Endothelial cell damage in patients with acute graft versus host disease receiving treatment with extracorporeal photopheresis - Scorecard - MDSpire

Endothelial cell damage in patients with acute graft versus host disease receiving treatment with extracorporeal photopheresis

  • By

  • Julia Martinez-Sanchez

  • Paola Charry

  • Ana Belén Moreno-Castaño

  • Alex Ramos

  • Sergi Torramade-Moix

  • Helena Ventosa-Capell

  • Marta Palomo

  • Olaf Penack

  • María Queralt Salas

  • María Suárez-Lledó

  • Francesc Fernández-Avilés

  • Carmen Martínez

  • Laura Rosiñol

  • Montserrat Rovira

  • Enric Carreras

  • Miquel Lozano

  • Gines Escolar

  • Joan Cid

  • Maribel Diaz-Ricart

  • June 15, 2026

  • 0 min

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Clinical Scorecard: Endothelial Injury in Acute Graft Versus Host Disease Patients Undergoing Extracorporeal Photopheresis Treatment

At a Glance

CategoryDetail
Condition
Key Mechanisms
Target Population
Care Setting

Key Highlights

  • ECP is a safe, effective treatment for SR-aGVHD.
  • Endothelial damage biomarkers were elevated in all patients before ECP.
  • A panel of 5 biomarkers can identify good responders to ECP.
  • ECP is generally reserved for third-line use in SR-aGVHD.
  • Endothelial damage is aggravated in allo-HCT recipients with aGVHD.

Guideline-Based Recommendations

Diagnosis

    Management

    • ECP is used as a third-line therapy for SR-aGVHD.

    Monitoring & Follow-up

      Risks

        Patient & Prescribing Data

        Adult patients with SR-aGVHD undergoing ECP.

        ECP is not immunosuppressive and does not negatively impact graft-versus-malignancy.

        Clinical Best Practices

        • Monitor endothelial damage biomarkers before and after ECP.
        • Consider combining ECP with ruxolitinib in severe cases.

        Related Resources & Content

        Original Source(s)

        Endothelial cell damage in patients with acute graft versus host disease receiving treatment with extracorporeal photopheresis

        • by Julia Martinez-Sanchez, Paola Charry, Ana Belén Moreno-Castaño, Alex Ramos, Sergi Torramade-Moix, Helena Ventosa-Capell, Marta Palomo, Olaf Penack, María Queralt Salas, María Suárez-Lledó, Francesc Fernández-Avilés, Carmen Martínez, Laura Rosiñol, Montserrat Rovira, Enric Carreras, Miquel Lozano, Gines Escolar, Joan Cid, Maribel Diaz-Ricart

        • June 15, 2026

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