Treatment first, transport second: rethinking stroke management with mobile stroke units—A systematic review and meta-analysis of controlled trials - Scorecard - MDSpire
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Prioritizing Treatment Over Transport: A Systematic Review and Meta-Analysis of Controlled Trials on Mobile Stroke Units in Stroke Management

  • By

  • Aishah Ibrahim Albakr

  • Ziyad Masoud Alqahtani

  • Abdulmonem Mohammed AlSharidah

  • Adel Abdalla Zeidan

  • Ahmed Abdulrahman Al Ibrahim

  • Mohammed Abdulmonem Al Zaher

  • Khurshid Khan

  • September 3, 2026

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Clinical Scorecard: Prioritizing Treatment Over Transport: A Systematic Review and Meta-Analysis of Controlled Trials on Mobile Stroke Units in Stroke Management

At a Glance

CategoryDetail
ConditionStroke
Key MechanismsMobile stroke units (MSUs) reduce critical time intervals in acute stroke care by providing on-site diagnosis and treatment capabilities.
Target PopulationPatients with suspected acute stroke.
Care SettingPrehospital environment with mobile stroke units.

Key Highlights

  • MSUs reduced the pooled median time to treatment by 26.3 minutes compared to traditional EMS.
  • No significant difference in safety outcomes between MSUs and EMS.
  • Remote neurologist configurations in MSUs are potentially cost-effective.

Guideline-Based Recommendations

Diagnosis

  • Utilize MSUs for rapid diagnosis and treatment of suspected acute stroke.

Management

  • Implement thrombolytic therapy on-site when eligibility criteria are met.

Monitoring & Follow-up

  • Assess functional recovery and safety profiles in patients treated by MSUs.

Risks

  • Monitor for intracranial hemorrhage and mortality rates, which showed no significant differences.

Patient & Prescribing Data

Patients with suspected acute stroke requiring timely intervention.

MSUs enable earlier treatment initiation, potentially improving clinical outcomes.

Clinical Best Practices

  • Incorporate telemedicine and neuroimaging in prehospital stroke care.
  • Train personnel in MSUs to assess and administer thrombolysis effectively.

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