Divergent risk profiles for cause-specific mortality in MASLD and MetALD: a nationwide population-based study
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By
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Hyuk Kim
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Jeong-Ju Yoo
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Young Chang
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Jae Young Jang
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Tom Ryu
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Soung Won Jeong
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Sang Gyune Kim
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Young Seok Kim
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Suyeon Park
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June 23, 2026
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Clinical Scorecard: Distinct Mortality Risk Factors in MASLD and MetALD: Insights from a Nationwide Population Study
At a Glance
| Category | Detail |
|---|
| Condition | Metabolic-dysfunction-associated steatotic liver disease (MASLD) and MetALD |
| Key Mechanisms | Impact of metabolic, behavioral, and sociodemographic characteristics on mortality rates |
| Target Population | Adults aged 20-79 years in South Korea |
| Care Setting | Nationwide health and nutrition examination surveys |
Key Highlights
- MASLD and MetALD linked to increased all-cause mortality compared to controls.
- MetALD showed a higher hazard ratio for all-cause mortality (HR 2.085).
- Cancer-related mortality significantly higher in both MASLD and MetALD groups.
- Excessive alcohol intake and smoking are independent predictors of mortality in MetALD.
- Sociodemographic factors such as gender and income influence mortality rates in MASLD.
Guideline-Based Recommendations
Diagnosis
- Utilize the hepatic steatosis index (HSI) for identifying MASLD.
Management
- Address alcohol consumption and cardiometabolic risk factors in MetALD.
Monitoring & Follow-up
- Monitor all-cause and cause-specific mortality in patients with MASLD and MetALD.
Risks
- Increased risk of cancer-related mortality in MASLD and MetALD.
Patient & Prescribing Data
Adults aged 20-79 years without prior cancer, cardiovascular disorders, or viral hepatitis.
Focus on lifestyle modifications and management of CMRFs in MASLD and MetALD.
Clinical Best Practices
- Regular assessment of alcohol intake and smoking habits in patients with MetALD.
- Consider sociodemographic factors when evaluating mortality risk in MASLD.
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